用作核磁共振造影增强剂的氧化铁溶液理化性质测定  

Determination of physical and chemical properties of the iron oxide solution to be used as a contrast agent for NMR

作　　者：钱建华[1] 杨凯[1] 范我[1] 宋建荣[1] 汪长源[1] 胡明江[1] 彭运开[1] 

机构地区：[1]苏州大学放射医学系,苏州215007

出　　处：《核技术》2001年第6期487-490,共4页Nuclear Techniques

基　　金：核工业科研基金! (J95Q6 2 0 10 )资助部分工作在核工业核医学重点实验室完成

摘　　要：为探讨大分子包埋氧化铁微粒溶液用作核磁共振造影增强剂的可能性 ,测定其铁含量、粘度、密度、分子大小、磁化率等理化性质 ;在核磁共振诊断仪上测定铁浓度随T1、T2信号强度的变化。结果表明 ,得到氧化铁微粒溶液的铁浓度为 8.5g/L ,用电镜测定的颗粒大小为 10nm ,粘度为0 .0 0 168Pa·s,当微粒溶液铁浓度为 0 .1mmol/L时 ,T2信号强度的下降大于 50 % ,T1信号强度在铁浓度为 0 .2— 0 .4mmol/L时 ,有一峰值 ,然后下降。溶液放置 1年 ,无大颗粒和明显沉淀物出现。说明本实验制备的葡聚糖包埋氧化铁溶液颗粒均匀 ,悬浮性好 ,在核磁共振诊断仪上显示出 ,随着铁浓度的增加 ,T2信号强度下降快 ,适于用作核磁共振造影的阴性增强剂。The purpose of this article is to determine physical and chemical properties of the iron oxide solution prepared in our laboratory and to evaluate the possibility for using it as a nuclear magnetic resonance contrast agent. The iron concentration and viscosity of the solution were found to be 0.15 mol/L and 0.00168 Pa·s, respectively, the particle size of the iron core was about 10nm determined with a transmission electronic telescope. The susceptibility increased with increasing iron concentration. The T2 signal intensity decreased by more than 50% at iron concentration of 0.1mmol/L, there was a peak of T1 signal intensity at iron concentration of 0.2—0.4mmol/L. No precipitate was observed in the solution after storing for one year. It was concluded good homogeneity and suspensibility of the iron solution were obtained. The significant decrease of T2 signal intensity with iron concentration shows that the solution was a promising contrast agent for magnetic resonance imaging.

关 键 词：氧化铁 磁共振造影剂 增强剂 物理性质 化学性质 测定 

分 类 号：R445.2[医药卫生—影像医学与核医学]