新生儿乙型肝炎疫苗免疫后13年效果观察  

Long term efficacy of vaccination against hepatitis B in newborns: 13 years' follow up

作　　者：吴维寿 孙超美 姜铭波 徐元 张国华 刘崇柏[2] 曹惠霖[2] 林曦敏[3] 徐志一[3] 

机构地区：[1]上海市南市区卫生防疫站防疫计免科,上海黄浦区疾病预防控制中心200011 [2]中国预防医学科学院病毒学研究所肝炎室 [3]上海医科大学流行病学教研室

出　　处：《中华实验和临床病毒学杂志》2001年第3期239-241,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的　研究乙型肝炎的远期免疫效果。方法　采用单纯随机方法连续 13年对 1986年出生并接种乙型肝炎疫苗的儿童进行隔年随访 ,采血检测HBsAg、抗 HBs、抗 HBc。结果　 13年间HBsAg阳性率在 0 46 %～ 0 97%之间 ,未随免疫时间的延长而上升 ,乙型肝炎疫苗的远期保护效果为81 67% ,与近期免疫效果相当。结论　免疫后Objective To evaluate long term efficacy of hepatitis B vaccination in newborns.Methods In the past 13 years we followed up the children who had been immunized with hepatitis B vaccine at birth in 1986 every other year. At each follow up visit, every child was tested for HBsAg, anti HBs and anti HBc.Results HBsAg positive rate of these birth cohort was low (range between 0 46% and 0 98%) during 13 years' follow up. Long term efficacy of the vaccination in preventing HBsAg carriage was confirmed.Conclusion Thirteen years later no booster was after needed.

关 键 词：病毒性肝炎疫苗 乙型肝炎表面抗原 新生儿 免疫 

分 类 号：R186[医药卫生—流行病学]