肾综合征出血热Ⅰ型灭活疫苗免疫后4年抗体水平监测  

Comparative study on antibody levels of vaccination group and control group after 4 years of immunized with type Ⅰ inactivated vaccine against hemorrhagic fever with renal syndrome

作　　者：阮玉华[1] 柳炜[2] 徐校平[3] 翁寿清[3] 邵守坤[3] 周卫群[3] 童政[3] 顾惠心[2] 朱智勇[4] 徐志一[2] 

机构地区：[1]中国预防医学科学院全国计划免疫技术指导中心,北京100050 [2]上海医科大学流行病学教研室 [3]浙江省建德市卫生防疫站 [4]浙江省卫生防疫站出血热重点实验室

出　　处：《中华实验和临床病毒学杂志》2001年第3期274-276,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的　比较肾综合征出血热 (HFRS)Ⅰ型灭活疫苗接种组和对照组免后 4年抗体水平 ,了解HFRSⅠ型灭活疫苗有无增强接种组隐性感染发生情况。方法　 1994年 7月～ 1998年 7月在建德市肾综合征出血热Ⅰ型灭活疫苗随机对照试验现场 ,采集接种组和对照组双份血清各 30 5和 2 83人。分别按对照组免前间接荧光抗体阳性和阴性的第二份血清间接荧光抗体滴度分布情况确定阳性判断阈值 (cut off值 ) ,由此判断免前间接荧光抗体阳性和阴性的接种组人群发生隐性感染情况。结果　以不同的cut off值来比较接种组和对照组免前间接荧光抗体阳性人群的抗体阳性率 ,差异无显著性。在免前间接荧光抗体阴性接种组和对照组中 ,其差异也无显著性。未见接种组和对照组免后抗体几何平均滴度和抗体阴转率差异有显著性。结论　接种组同对照组免后 4年荧光抗体水平差异无显著性 。Objective To compare the antibody level of vaccine group and control group in a randomized, controlled trial of type Ⅰ inactivated vaccine against hemorrhagic fever with renal syndrome(HFRS) in Jiande County of Zhejiang Province and to find out if there is enhancement of subclinical infection about type Ⅰ inactivated vaccine against HFRS.Methods The number of sera collected (July 1994 July 1998 ) in vaccine group immunized type Ⅰ inactivated vaccine against HFRS and control group were 305 and 283 persons in Jiande County respectively,and indirect immunofluorescent antibody method(IFAT) was used for testing the titer of HFRS IgG in sera,The cut off values were determined on IFA titer of the second sera in control group with positive and negative IFA before vaccine was given respectively,and the subclinical infection of positive and negative IFA of the first sera in vaccine group was evaluated.Results When taking different cut off values of subclinical infection, there were no statistical differences in HFRS IFA positive rates between vaccine group and control group of positive IFA in the first sera.In vaccine group and control group of negative IFA before vaccine given,also the IFA positive rates were not statistically different in these groups.There were no statistical differences of IFA GMT and IFA sero negative rate between vaccine group and control group.Conclusions The investigation showed there was no statistical difference in antibody level between vaccine group and control group,so there could not be enhancement of subclinical infection of vaccine group receiving type Ⅰ inactivated vaccine against HFRS.

关 键 词：灭活疫苗 感染 免疫性移植物增强 肾综合征出血热 

分 类 号：R186[医药卫生—流行病学]