产妇弓形虫感染对新生儿影响的研究  

STUDY ON TOXOPLASMA GONDII INFECTION OF PARTURIENT WOMEN AND ITS EFFECTS ON NEW BORN INFANTS

作　　者：闫旭霞[1] 李书梅 李爱民[1] 杜梅林 宋菊先 朱新鹏[1] 

机构地区：[1]河南省卫生防疫站原虫病防治科,河南郑州450003 [2]开封市妇产医院

出　　处：《中国寄生虫病防治杂志》2001年第3期185-187,共3页Chinese Journal of Parasitic Disease Control

摘　　要：目的　探讨孕妇弓形虫感染对胎儿的影响。　方法　采用酶免三联诊断法对 35 6例母婴配对标本进行血清学检测。　结果　产妇弓形虫感染率平均为 19.1% ,各单项检测分别为 CAg15 .2 %、Ig M2 .5 %、Ig G3.4% ;新生儿弓形虫感染率平均为 17.7% ,其脐血各单项检测分别为 CAg16 .9%、Ig M0 .3%、Ig G2 .2 %。CAg垂直传播率为 35 .2 % (19/5 4) ,Ig G垂直传播率为 33.3% (4/ 12 )。在 4例畸胎儿中 ,2例脐血弓形虫血清学阳性。　结论　孕妇感染弓形虫有 1/ 3机会可通过胎盘垂直感染胎儿 ,影响胎儿发育 ,重者致畸。Objective To explore the effects on new born infants after pregnant women infected with Toxoplasma gondii. Methods Matched blood samples were collected from 356 paired mothers and babies to detect the infection of T. gondii. An ELISA triple diagnostic reagent was used for the test of circulating antigen (CAg), antitoxoplasma antibodies IgM and IgG. Results The average infection rate of Toxoplasma in pregnant women was 19.1%, among them the positive rate of CAg, IgM and IgG was 16.9%, 0.3% and 2.2% respectively. From the matched infant samples, the proportion of vertical transmission of CAg was 35.2% (19/54) and IgG was 33.3% (4/12). The results indicated that near one third fetus were infected from their mothers before gave birth. 4 cases of congenital malformation were investigated, among them 2 serum samples were positive. Conclusion About one third fetus were able to get infection through placenta from their mothers which caused vertical transmission before gave birth and the development of fetus could be impaired even malformation and death.

关 键 词：弓形虫 产妇 新生儿 循环抗原 特异性抗体 

分 类 号：R382.5[医药卫生—医学寄生虫学]