探讨SPECT肝细胞显像评价肝硬化程度  

Evaluation of the Degree of Hepatocirrhosis with Liver Cell Imaging by SPECT

作　　者：程木华[1] 凌云彪[1] 潘志恒[1] 汪壮流[1] 张峰[1] 陈维真[1] 

机构地区：[1]中山医科大学附属第三医院,广州510630

出　　处：《现代临床医学生物工程学杂志》2001年第3期166-168,共3页Journal of Modern Clinical Medical Bioengineering

基　　金：广东省卫生厅基金资助

摘　　要：目的　评价肝硬化患者的肝细胞功能及肝硬化程度 .方法　对 2 5例肝硬化患者及 13例正常对照组 ,进行肝胆动态显像 ,通过三室模型获得肝细胞摄取、排泄功能的放射性 -时间曲线 ,计算肝细胞摄取和排泄等功能指标 .结果　肝硬化组高峰时间、平均残存时间均显著高于正常对照组 ,均p <0 .0 0 1.肝硬化组与正常组比较高峰值摄取指数、摄取斜率、排泄斜率均显著降低 ,均p <0 .0 1.结论　肝细胞显像是一种灵敏评价肝细胞代谢功能的无创性方法 。Objective To evaluate the damaging degree of hepatic cell in the patients with hepatocirrhosis. Methods 25 cases of hepatocirrhosis and 13 cases of normal controls were performed the dynamic imaging with 99mTc-EHIDA. By the three compartmental model configurations, we acquired the time-activity curves of the liver cell, and calculated the function indexes of liver cell extraction and excretion . Results The peak time and mean residence time in the hepatocirrhosis groups were higher than those in the normal controls,p< 0.001. Compared to normal controls, the peak value,index of uptake,take slope,and excretion slope of the hepatocirrhosis were all lower,p<0.01. Conclusions Liver cell imaging was a better method for reflecting the change of liver cell functions, and may analyse the degree of hepatocirrhosis.

关 键 词：肝硬化 肝细胞功能 放射性核素显像 肝细胞显像 

分 类 号：R817.4[医药卫生—影像医学与核医学] R575.2[医药卫生—放射医学]