CTGF与FGF在促成纤维细胞增殖过程中的基因反应差异  

THE DIFFERENT GENE RESPONSE IN THE PROCEDURE OF FIBROBLAST PROLIFERATION INDUCED BY CTGF AND FGF

作　　者：王炯[1] 董承红[1] 王丽春[1] 孙明[1] 李琦涵[1] 

机构地区：[1]中国医学科学院 中国协和医科大学 医学生物学研究所,昆明650118

出　　处：《细胞生物学杂志》2001年第3期169-173,共5页Chinese Journal of Cell Biology

基　　金：国家新药开发与应用基金(项目编号96-901-05-134);卫生部面上基金(项目编号983-2-003)

摘　　要：结缔组织生长因子(CTGF)是某些内皮细胞即刻早期基因反应产物,其与FGF具有类似的促进成纤维细胞(KMB-17)增殖的功能;在此促增殖过程中CTGF和FGF所诱导的基因反应有所差异,CTGF诱导细胞表达c-myc,而FGF促进c-fos表达增加;此外两种因子均诱导与酪氨酸磷酸化过程密切相关的src基因表达,免疫沉淀证实CTGF结合细胞表面受体后可诱导细胞内相应蛋白的酪氨酸磷酸化。Connective Tissue Growth Factor(CTGF)is a product of immediately early gene, which has the similar effect of stimulating fibroblast proliferation as FGF,but CTGF and FGF have different gene response in this process, CTGF induced cell expression of c-myc oncogene,FGF stimulated c-fos oncogene expression;on the other hand CTGF and FGF both can induce src gene expression and the result of the immunological precipitation with anti-phosphotyrosine antibody suggested that tyrosine phosphorylation of a protein in KMB-17 perhaps is related with the signal transduction of CTGF.

关 键 词：CTGF FGF 成纤维细胞增殖 基因反应差异 蛋白磷酸化 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]