EXPRESSION EFFECT OF (-CHO) AFTER LONG-TERM TREATMENT OF OPIATES AND THE RELATIONSHIP WITH MITOCHNDRIAL MEMBRANE POTENTIAL IN P[C12 CELLS  

作　　者：Jiu－Yi LU Lee－Yun LIU－CHEN 等 

出　　处：《神经解剖学杂志》2001年第B07期120-120,共1页Chinese Journal of Neuroanatomy

摘　　要：Many opioids-mediated responses, including the inhibition of forskolin-stimulated cyclic-AMP accumulation, the activation of an inwardly rectifying K^+ channel, and antinociception, are diminished by repeated exposure to selective agonists. This loss of receptor sensitivity and function results in desensitization, down-regulation and the development of opiate tolerance. In our research, we are supposed to find out

关 键 词：鸦片制剂 长期处理 CHO细胞 PC12细胞 线粒体膜电位 

分 类 号：R971.2[医药卫生—药品]