络泰对大鼠实验性急性心肌缺血的保护作用及抗脂质过氧化作用  

PROTECTIVE EFFECTS OF LUOTAI POWDERED INJECTIONS ISOLATED FROM TOTAL SAPONINS OF PANAX NOTOGINSENG ON MYOCARDIAL ISCHEMIA IN EXPERIMENTAL MYOCARDIAL ISCHEMIA INJURY MODEL ON RATS

作　　者：雷秀玲[1] 董雪峰 陈植和[3] 李玲[3] 

机构地区：[1]昆明医学院基础药理教研室,昆明650031 [2]云南滇虹药业有限公司,昆明650101 [3]云南省天然药物药理重点实验室,昆明医学院昆明650031

出　　处：《天然产物研究与开发》2001年第4期58-61,共4页Natural Product Research and Development

基　　金：云南省自然科学青年基金资助项目No :96C0 76Q&&

摘　　要：采用结扎大鼠冠脉造成急性心肌缺血模型 ,观察了络泰 (三七总皂甙的新剂型 )抗实验性心肌缺血作用。结果表明 ,络泰对大鼠实验性急性心肌缺血有一定程度的保护作用 ,本品 5 0mg/kg显著减少心电图S T段的上移 (P <0 0 1) :络泰 5mg/kg、5 0mg/kg和 10 0mg/kg均显著降低血清CPK(P <0 0 5 ,P<0 0 1) ;在缩小心肌梗塞范围方面也有一定作用 ,但统计学上没有显著性。络泰三个剂量组能显著提高SOD活性 (P <0 0 1) ,降低MDA水平 (P <0 0 5 ) ;本品 5 0mg/kg和 10 0mg/kg还能显著增加心肌缺血时血中PGI2 水平 (P <0 0 5 ) ,提示络泰对心肌缺血的保护作用与抗脂质过氧化作用有关 ,其促进PGI2Powdered injections of Luotai isolated from Total Saponins of Panax notoginseng which protected against myocardial ischemia injury.It was considered as the treatment of coronary heart disease in folk.In this paper,an acute myocardial ischemia model by ligaturing left descending coronary artery on rat was made,which increased S T sigments in ECG.Luotai at 50 mg/kg significantly inhibited S T sigment raise,also narrowed myocardial infract size,decreased cardiac CPK levels.Luotai at 5 mg/kg,50 mg/kg and 100 mg/kg significantly increased superoxide dismutase(SOD)activities,reduced malondialdehyde(MDA)products.Luotai also increased composes of PGI 2 in serum after experimental acute myocardial ischemia.The results show that Luotai can protect against cardiac ischemia injury and the action is considered to relate to the inhibition of lipid peroxidation.

关 键 词：络泰 实验性心肌缺血 LDH CPK SOD MDA PGI2 TXA2 药理 保护作用 脂质过氧化 

分 类 号：R972.3[医药卫生—药品]