电穿孔下分子型药物透皮扩散的一类数学模型  

A KIND OF MATHEMATICAL MODEL OF TRANSDERMALPERMEATION OF MOLECULAR DRUG THROUGH ELECTROPORATION

作　　者：吴建军[1] 

机构地区：[1]浙江大学理学院数学系,浙江杭州310006

出　　处：《生物物理学报》2001年第3期592-598,共7页Acta Biophysica Sinica

基　　金：国家自然科学基金资助项目(编号39670857)

摘　　要：针对电穿孔可致使皮肤产生水性新通道的现象 ,在Fick扩散律和快 -慢响应双通道假设下 ,给出了分子型药物经皮渗透过程的一类数学模型。经计算机模拟 ,发现其特征与实验数据高度一致。最后简要地讨论了此模型的优缺点和适用性等。A kind of mathematical model of transdermal diffusion of molecular drug through aqueous pores caused by electroporation is given. The model consists of Fick's diffusion law with quick and slow two respondences separately. By computer simulation,it is found that the characteristic is highly consistent with that of a lot of experiment data. Finally, advantages and disadvantages, as concerned with application of the model are discussed briefly.

关 键 词：电脉冲穿孔 透皮扩散 数学模型 分子型药物 

分 类 号：R911[医药卫生—药学] R945