氟苯水杨酸  

Diflunsial

作　　者：瞿军[1] 

机构地区：[1]江苏省化工研究所

出　　处：《精细与专用化学品》2001年第15期8-9,共2页Fine and Specialty Chemicals

摘　　要：氟苯水杨酸副作用小、强效、低毒,是阿司匹林很好的替代产品。公认的可工业化的生产方法是以2,4-二氟苯胺为原料,经偶联、酰化、水解、羧化等一系列反应制备。氟苯水杨酸已经在欧美、日本等70多个国家得到了广泛应用,年销售额超过1亿美元;我国浙江大学和巨化集团都对氟苯水杨酸进行了研究和开发工作,但国内尚没有工业化生产。制约氟苯水杨酸推广应用的主要原因是价格昂贵,这有赖于生产技术进步来解决。Diflunsial is an excellent substitute product to penicillin, which is characterized by little side-effect, high efficacy and lower toxicity. The accepted commercial process is based on 2,4-difuloroaniline, through coupling, acyla-tion, hydrolysis and carboxylation reactions. Diflunsial has been widely applied in more than 70 countries and regions including Europe, the U. S. and Japan with annual sales over US $ 100m. In China, Zhejiang University and Juhua Group Corporation have undertaken the R&D of diflunsial, but there is no commercial production domestically. The high price of diflunsial has limited its popularization and application. The solution lies on the progress of manufacturing technology.

关 键 词：氟苯水杨酸 阿司匹林 2 4-二氟苯胺 药物 

分 类 号：TQ464[化学工程—制药化工]