灯盏花中两个新化合物的分离和鉴定  

Isolation and identification of two new compounds from Erigeron breviscapus

作　　者：张卫东[1] 陈万生[1] 王永红[1] 刘文庸[1] 孔德云[2] 李惠庭[2] HA Thi Bang Tam 

机构地区：[1]第二军医大学药学院,上海200433 [2]上海医药工业研究院,上海200040 [3]法国图卢兹大学药学院

出　　处：《中草药》2001年第7期577-579,共3页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目 No2 9972 0 5 4

摘　　要：目的　探索菊科植物灯盏花 Erigeron breviscapus的化学成分。方法　采用各种色谱分离技术 ,理化常数和光谱分析鉴定了化合物的结构。结果　从灯盏花的乙醇提取物中分得了 2个化合物 ,经光谱学分析鉴定它们的结构分别为 :1-羟基 - 2 ,3 ,5 -三甲氧基酮 ( 1- hydroxy- 2 ,3 ,5 - trim ethoxy xanthone, ) ,1- ( 2′-γ-吡喃酮 ) - 6-咖啡酰基 -α- D-吡喃葡萄糖苷 ( 1- 2′- γ- pyranone) - 6- caffeoyl- α- D- pyranoglucose, )。结论　化合物 , 为新化合物。化合物 对 TNF-α诱导的内皮细胞粘附有一定的抑制作用。提示它对缺血再灌注损伤有保护作用。Object To investigate the chemical constituents of Erigeron breviscapus (Vant.) Hand. Mazz. (Compositae) Methods Compounds were isolated from the ethanolic extract with column chromatography and identified on the basis of spectral analysis (IR, EI MS, FAB MS, 1HNMR, 13 CNMR, 2DNMR) and physiochemical properties Results Two compounds were identified as 1 hydroxy 2,3,5 trimethoxy xanthone (Ⅴ), and 1 (2′ γ pyranone) 6 caffeoyl α D pyranoglucose (Ⅵ) Conclusion Both of the two compounds were new Compound Ⅵ showed inhibitory effects on the adhesion of endothelial induced by TNF α, indicating its protective effect against injury due to ischemic reperfusion

关 键 词：灯盏花 1-羟基-2 3 5-三甲氧基Shan酮 1-(2'-γ-吡喃酮)-6-咖啡酰基-α-D-吡喃葡萄糖苷 化学成分 

分 类 号：R284.1[医药卫生—中药学]