四抗感冒口服液的抗炎作用和对小鼠脾淋巴细胞功能的影响  

Effects of Sikang ganmao oral liquores on the anti-inflammation and the splenocyte immune function

作　　者：郑芙林[1] 徐冰[1] 刘家全[2] 于旺银[3] 陈铎保[1] 李兵[1] 张雷[1] 

机构地区：[1]淮南工业学院医学分院,淮南232001 [2]中国基层医学杂志社,淮南232007 [3]安徽淮南市第一人民医院,淮南232007

出　　处：《安徽医科大学学报》2001年第3期194-196,共3页Acta Universitatis Medicinalis Anhui

摘　　要：目的　研究四抗感冒口服液 (CCD)的抗炎作用和对免疫细胞功能的影响和急性毒性反应。方法　鼠耳肿胀法、小鼠脾淋巴细胞增殖法、小鼠ig急性毒性试验 (最大耐受量测定 )。结果　CCD 2 5～ 10 0g·kg-1对鼠耳肿胀有明显抑制作用。CCD 0 5mg·L-1对刀豆球蛋白A诱导小鼠T淋巴细胞增殖反应有明显促进作用 ,对脂多糖诱导B淋巴细胞增殖反应无明显影响。小鼠ig的最大耐受量 (MTD) >80 g·kg-1。结论　CCD具有抗炎、增强细胞免疫功能的作用。Objective To study the effects of Sikang ganmao oral liquores(CCD) on anti inflammation,functions of immune cells and acute toxicity.Methods Model of the swelling of mouse ear,lymphocyte proliferation response and acute toxicity test were used.Results CCD 2.5～10.0 g·kg -1 showed marked suppressive effect on inflammatory model.CCD 0.5 mg·L -1 enhanced splenocyte proliferation induced by concanavalin A.CCD did not promote splenocyte proliferation induced by lipopolysaccharide.The maximal tolerant dose(MTD) of CCD by ig in mice was 80 g·kg -1 .Conclusion CCD has the anti inflammatory and immunoenhancement effects.CCD is safe for oral use.

关 键 词：抗炎 四抗感冒口服液 中药 CCD 脾淋巴细胞功能 小鼠 

分 类 号：R285.5[医药卫生—中药学]