盐酸左氧氟沙星注射液随机对照治疗细菌性感染临床试验研究  

A Randomized Controlled Clinical Study on Levofloxacin Versus Ciprofloxacin in the Treatment of Bacterial Infections

作　　者：郑波[1] 李家泰[1] 吕媛[1] 陈扬[1] 

机构地区：[1]北京大学第一医院

出　　处：《中国临床药理学杂志》2001年第4期243-246,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的：以环丙沙星注射液作为对照药，进行随机对照临床试验，评价盐酸左氧氟沙星注射液治疗细菌性感染的安全有效性。方法：本试验采用随机对照试验设计方法，完成可评估病例５２例，其中试验组２５例，对照组２７例。结果：临床有效率试验组为８８．００％，对照组为８５．１９％，各种致病菌清除率试验组为 ９５．６５％，对照组为 ８９．４７％，药物不良反应率分别为４％和 ７．４１％。两组统计学处理差异无显著性（Ｐ＞０．０５）。结论：表明采用盐酸左氧氟沙星治疗急性细菌性感染安全、有效。Levofloxacin is a fluoroquinolones with a broad spectrum of antibacterial activity. A randomized controlled clinical study of levofloxacin was conducted campared with ciprofloxacin. The objective of the study is to evaluate the safety and efficacy of levofloxacin in the treatment of bacterial infections. A total of 52 patiens was enrolled in the study. 25 patients received levofloxacin and 27 patients received ciprofloxacin were assessable for clinical efficacy. The result showed that the overall efficacy rates were 88.00% for the levofloxacin group and 85. 19% for the ciprofloxacin group, whereas the bacterial clearance rates were 95.65% and 89.47%, respectively. The adverse ding reaction rate were 4.00% and 7.41 %, respectively. The results showed that levofloxacin was effective and safe for the treatment of bacterial infections. There were no statistical differences between the two groups (P>0.05).

关 键 词：左氧氟沙星 环丙沙星 随机对照 细菌性感染 药物治疗 

分 类 号：R515[医药卫生—内科学]