甲型肝炎减毒活疫苗H_2株免疫后3年的血清学效果研究  

Immunogenicity of a live attenuated hepatitis A vaccine (H_2 strain) in 3 years

作　　者：韦再华[1] 吴淑慧 张勇 李国庆[2] 张世勇[3] 刘新立[3] 侯通[3] 夏建玲 李艳洁 

机构地区：[1]河北医科大学公共卫生学院流行病学教研室 [2]河北职工医学院 [3]石家庄市卫生防疫站 [4]石家庄市郊区防疫站

出　　处：《中国全科医学》2001年第8期607-608,共2页Chinese General Practice

基　　金：国家"九五"攻关题目 (编号 :96 -90 6 -0 3 0 1);河北省自然科学基金项目 (编号 3 972 76 )

摘　　要：目的　研究规范化H2 株甲型肝炎 (简称甲肝 )减毒活疫苗免疫学效果和抗感染能力。方法　从30 42名 6～ 13岁儿童中筛选出甲肝病毒易感者 1117名 ,将他们随机分为疫苗组和对照组。疫苗组在接种后 6、36个月随机采样抽血检测血清甲肝抗体 (抗 -HAV)。结果　免疫后 6个月抗体转阳率达 92 8% ,几何平均滴度(GMT)为 1∶4 68。免疫后 36个月抗体阳性率为 92 3% ,GMT为 1∶2 75。免疫后 36个月疫苗组感染率为16 4% ,对照组感染率为 13 1% ,两组差异无显著性 (χ2 =2 44 ,P >0 0 5 )。结论　本疫苗具有良好的免疫原性。疫苗抗体可能只有抗发病能力 。Objective To assess immunogenicity of a standardized live attenuated hepatitis A vaccine(H 2 strain).Methods 1117 susceptible of HAV were screened from 3042 children of 6～13 years old.Those susceptible children were divided into HAV vaccine group and control group at random.The vaccine group was bled at 6 months and both the vaccine and control group 36 months after the vaccination and tested for anti-HAV by random sampling.Results The seroconversion rates were 92 8% and 92 3% in 6 and 36 months respectively,and the GMTs were 1∶4 68 and 1∶2 75 respectively after the immunization.In 36 months the infection rate was 16 4% for vaccine group,the infection rate was 13 1% for control group.There was no significant difference between two groups (χ 2=2 44,P>0 05).Conclusion The study well confirmed the immunogenicity of the vaccine,and indicated the antibody induced by the vaccine might be disease-resistance,not infection-resistance.

关 键 词：甲型肝炎减毒活疫苗 疫苗接种 免疫原性 血清学效果 

分 类 号：R512.61[医药卫生—内科学]