倒卵叶五加总皂甙抗心肌缺血再灌注心律失常的作用  

Effects of Saponin of Acanthopanax Obovatus Hoo on Arrhythmia Induced By Myocardial Ischemia/Reperfusion Injury in Rats

作　　者：马世玉[1] 明章银[1] 闵清[1] 吴基良[1] 李立中[1] 

机构地区：[1]咸宁医学院药理学教研室,湖北咸宁437100

出　　处：《咸宁医学院学报》2001年第3期157-159,共3页Journal of Xianning Medical College

基　　金：湖北省教育厅重点科研基金项目 (98A0 76 )

摘　　要：目的探讨倒卵叶五加总皂甙 (SAOH)对大鼠心肌缺血再灌注心律失常的影响。方法采用结扎左冠状动脉前降支的方法复制在体大鼠心肌缺血再灌注损伤 (IRI)的模型 ,结扎前 1 0分钟分别舌下静脉注射SAOH5 0mg/kg、1 0 0mg/kg ,分别观察SAOH对大鼠缺血 3 0分钟和 5分钟后再灌注的作用。 结果SAOH能消除大鼠缺血 3 0分钟再灌注 4 0分钟时室性心动过速 (VT)和室性颤动 (VF)的发生 ,并能显著降低缺血 5分钟再灌注 1 5分钟时心律失常的发生率和持续时间。Objective To study the effects of Saponin of Acanthopanax Obovatus Hoo (SAOH) on arrhythmia induced by myocardial ischemia reperfusion (IRI) in rat.Methods Arrhythmias were induced by left descending anterior coronary artery (LAD) ligation for 30 min, followed by 40 min of reperfusion,and myocardial ischemia for 5 min followed by reperfusion for 15 min.Results SAOH could precluded ventricular fibrillation (VF) and ventricular tachycardia (VT) in 40 min of reperfusion;Also,SAOH reduced the incidence and duration of arrhythmia during myocardial ischemia for 5 min followed by reperfusion for 15 min.Conclusion SAOH have anti arrhythmia effects induced by myocardial ischemia and reperfusion.

关 键 词：倒卵叶五加总皂甙 心肌缺血 再灌注损伤 心律失常 SAOH 大鼠 

分 类 号：R542.2[医药卫生—心血管疾病] R541.7[医药卫生—内科学]