应激性高血压大鼠PAG内微量注射L-NNA对血压的影响  

Effects of Microinjection of L-NNA into Midbrain Periaqueductal Gray on Blood Pressure in Stress-induced Hypertension Rats

作　　者：胡旺平[1] 化长林[2] 魏劲波[3] 

机构地区：[1]武汉大学医学院研究生,武汉430071 [2]咸宁医学院生理学教研室,咸宁437100 [3]武汉大学医学院生理学教研室,湖北武汉430071

出　　处：《咸宁医学院学报》2001年第3期160-162,共3页Journal of Xianning Medical College

摘　　要：目的研究中脑导水管周围灰质 (PAG)内NO在慢性应激导致大鼠高血压发病中的作用。方法采用电击足底结合噪声建立应激性高血压 (SIH)模型 ,通过向PAG内微量注射L NNA后 ,观察其对大鼠平均动脉压 (MAP)的影响。结果在正常大鼠PAG内注射L NNA后 ,动物MAP显著升高 ;而在应激性高血压 (SIH)大鼠PAG内注射L NNA后 ,与正常大鼠相比较升压效应明显降低。Ojective To study the role of nitric oxide in midbrain periaqueductal gray (PAG) on the incidence of rats′ chronic stress induced hypertension (SIH).Methods The model of SIH was established by foot electric shock combined with noise.The changes of mean arterial pressure (MAP) in rats were observed after microinjection of N nitro L arginine (L NNA) into PAG.Results Following microinjection of L NNA into PAG,MAP in control rats increased significantly,while the pressor effect of L NNA attenuated significantly in SIH rats.Conclusion The nitric oxide of PAG may participate in the development of SIH.

关 键 词：中脑导水管周围灰质 应激性高血压 硝基左旋精氨酸 血压 大鼠 

分 类 号：R544.1[医药卫生—心血管疾病]