青霉素V钾分散片的研制  

Research of phenoxymethylpenicillin potassium dispersible tablets

作　　者：彭毓芳[1] 贺林[1] 张志荣[2] 吴苏澄 蒋红艳 

机构地区：[1]成都市儿童医院,成都610017 [2]华西医科大学,成都610041 [3]成都军区总医院,成都610083

出　　处：《药学实践杂志》2001年第5期275-276,共2页Journal of Pharmaceutical Practice

摘　　要：目的：筛选青霉素Ｖ钾分散片的处方．建立青霉素Ｖ钾分散片的含量测定方法。方法：采用均匀设计法筛选处方；紫外分析法测定含量。结果：青霉素 Ｖ钾分散片崩解时限４５～９０ｓ，Ｔ５０ １．０９ｍｉｎ，Ｔｄ ２．０７ｍｉｎ；紫外测定回收率９７．５４％。结论：按本文处方生产的青霉素Ｖ钾分散片质量符合英国药典对分散片的要求；紫外方法快速、简便，准确度较高。OBJECTIVE: To optimize prescriptions of phenoxymethylpenicillin potassium (VK) dispersible tab- lets and establishe content measuring method. METHODS: Uniform design method and UV method were used. RE- SULTS:The results were as follows: breaking time 45 ~ 90s, T50 1. 09min, Td 2. 07min, recovery ratio 97. 54%. CONCLUSION:The quality of phenoxymethylpeniniclillin potassium dispersible tablets is conform to Britain Phar-macopoeia and UV method is simple and rapid.

关 键 词：青霉素V钾 分散片 均匀设计 含量 质量控制 

分 类 号：R978.11[医药卫生—药品] R944.4[医药卫生—药学]