褪黑激素明胶微球剂与溶液剂鼻粘膜给药比较  

Comparison of the differences between melatonin gelatin microspheres and solution in nasal delivery system

作　　者：陈建明[1] 叶丽卡[1] 高申[2] 毛世瑞[3] 毕殿洲[3] 

机构地区：[1]解放军第202医院药局,沈阳110003 [2]第二军医大学药学院药剂教研室,上海200433 [3]沈阳药科大学药剂教研室,沈阳110015

出　　处：《药学实践杂志》2001年第5期280-281,共2页Journal of Pharmaceutical Practice

摘　　要：目的：比较明胶微球剂与溶液剂的鼻粘膜给药。方法：通过鼻粘膜滞留时间及药物鼻粘膜吸收等实验，比较明胶微球及溶液２种给药制剂的区别。结果：明胶微球剂在鼻粘膜滞留时间明显比溶液剂长，能明显提高药物鼻粘膜吸收，并延长药物在体内滞留时间。结论：明胶微球明显提高药物鼻粘膜吸收，具有很好应用前景。OBJECTIVE: To compare the differences between gelatin microspheres and solution in nasal delivery system. METHODS : The residence time in nasal mucosa and nasal absorption experiments were performed respectively to compare the differences between gelatin microspheres and solution. RESIJLTS: The residence time of gelatin microspheres was longer than gelatin solution in nasal cavity, gelatin microspheres evidently raised melatonin nasal absorption and prolonged the retention time in blood circulation. CONCLUTION: Gelatin microspheres could raise melatonin nasal absorption and would have good application prospects.

关 键 词：明胶微球 溶液剂 鼻粘膜给药 褪黑激素 

分 类 号：R977.1[医药卫生—药品] R944.9[医药卫生—药学]