敷料用透湿性聚氨酯膜的性能及其影响因素  

Study on Preparation and Properties of Moisture Permeable Polyurethane Membrane Used for Dressings

作　　者：黄忠兵[1] 李伯刚[1] 胡英[1] 尹光福[1] 郑昌琼[1] 

机构地区：[1]四川大学生物医学工程中心,成都610065

出　　处：《生物医学工程学杂志》2001年第3期346-350,共5页Journal of Biomedical Engineering

基　　金：四川省应用基础基金资助课题 (川教科 95 (2 9))

摘　　要：我们用聚乙二醇 (PEG)代替普通聚醚 (PPG)合成了亲水性的聚氨酯 (PU)预聚体 ,然后将预聚体溶液流延成膜制成双层敷料的外层透湿膜。研究了 PEG分子量、交联剂用量、制膜溶剂及预聚体溶液中水含量对膜透湿性的影响。结果表明 :所制的膜是一种多孔结构的透湿膜 ;适宜的成膜条件为 :PEG的分子量 (Mn)为 2 0 0 0～ 40 0 0 ,交联剂用量为 5 .0 wt% ,成膜溶剂为丙酮与 N,N-二甲基 -甲酰胺的混合溶液 ,成膜温度为 5 0℃～ 80℃ ;所制膜的透湿率在 35℃下为 49～ 6 0 g/ m2 · h,能够满足敷料对透湿率的要求 ;A new hydrophilic polyurethane(PU) performed polymer has been developed with polyethylene glycol(PEG) instead of general polyether. The solution of performed polymer is poured casting a permeable membrane used for the outer layer of the bilayer dressings. The effects of molecular weigh (Mn) of PEG, the usage of cross link agents, solvents and water in the solution on the moisture permeation of PU membrane have been studied. It has been shown that the membrane prepared is a porous moisture permeable membrane. The optimum conditions of preparing membrane are: Mn of PEG is 2 000～4 000, the mixture of acetone and N,N dimethylformamide (DMF) is used as solvents, and the temperature of performance membrane is 50 ℃～80 ℃. The moisture permeability of the PU membrane is 49～60 g/m 2·h at 35℃, which can meet the requirement of the wound dressings. In addition, the mechanism of the moisture permeation of PU membrane has been discussed.

关 键 词：亲水性 聚氨酯 创伤敷料 透湿膜 透湿性 

分 类 号：R318.08[医药卫生—生物医学工程]