实验性低血压大鼠动脉的生物力学特性  

Biomechanical Properties of Arteries in Experimental Hypotensive Rats

作　　者：姜宗来[1] 李洪海[1] 刘波[1] 滕忠照[2] 覃开荣[2] 

机构地区：[1]第二军医大学生物医学工程研究所,上海200433 [2]复旦大学生物力学实验室,上海200433

出　　处：《生物医学工程学杂志》2001年第3期381-384,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 (19672 0 72 )

摘　　要：为了研究低血压状态下动脉重建后 ,动脉的生物力学特性的变化 ,在大鼠左肾动脉起点以下缩窄腹主动脉 ,建立实验性低血压大鼠模型 ,按不同的时相点 ,观测腹主动脉、股动脉和胫前动脉张开角的变化 ,并进行在体腹主动脉的压力 -容积 (P- V)关系实验。结果显示 ,低血压大鼠的动脉血压降低 ,导致动脉壁的非均匀性生长 ,表现为动脉零应力状态下张开角减小。低血压状态时 ,腹主动脉的 C/ E比值减小 。To study the changes of biomechanical properties after arterial remodeling in hypotension, a model of hypotension was established in rats by constricting the abdominal aorta below the orifice of the left renal artery. The change of opening angles of the abdominal aorta, femoral artery and anterior tibial artery, and the compliance of the abdominal aorta were studied. The relationship between the pressure and volume of the abdominal aorta were also observed in vivo. The results show that non-uniformal remodeling of the hypotensive artery induces the reduction of opening angles in the zero-stress state, the C/E rate of the abdominal artery decreases while the compliance increases.

关 键 词：低血压 动脉重建 顺应性 张开角 生物力学 大鼠 

分 类 号：R318.01[医药卫生—生物医学工程]