冠心病患者血浆同型半胱氨酸水平变化的临床特点  

Plasma Homocysteine Levels of Patients with Coronary Heart Disease

作　　者：许海燕[1] 陈在嘉[1] 杨跃进[1] 惠汝太 张春玲[2] 陈纪林[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院冠心病研究室,北京市100037 [2]中德分子医学研究室

出　　处：《中国循环杂志》2001年第3期188-189,共2页Chinese Circulation Journal

摘　　要：目的：研究冠心病患者血浆同型半胱氨酸（Ｈｃｙ）水平变化的临床特点。 方法：采用高压液相色谱法测定２０９例冠心病患者（冠心病组）和１０１例正常人（正常对照组）血浆Ｈｃｙ水平。 结果：冠心病组血浆 Ｈｃｙ水平（２３． ４２±２６．８７μｍｏｌ／Ｌ）明显高于正常对照组（ １４． ９８±１３．０５μｍｏｌ／Ｌ），有非常显著差异（Ｐ＜０．００１），高Ｈｃｙ血症所占比例（４７．５％）高于正常对照组（２０．６％），有非常显著差异（Ｐ＜０．００１）。冠心病组男性血浆总 Ｈｃｙ水平（２４．８５±２８．３８μｍｏｌ／Ｌ）高于正常对照组男性（１５．５４±１２．８５μｍｏｌ／Ｌ），有非常显著差异（Ｐ＜０．００１），而在冠心病女性（１３．３３±４．８８μｍｏｌ／Ｌ）和正常对照组女性（１３．２３±１３．７５μｍｏｌ／Ｌ）之间没有差异。并且，急性心肌梗塞患者血浆总Ｈｃｙ水平明显高于心绞痛患者，零支、单支、双支、三支血管有病变者血浆总Ｈｃｙ水平呈逐级上升趋势。 结论：我国冠心病患者血浆总 Ｈｃｙ水平明显升高，高 Ｈｃｙ血症所占比例较大，而 Ｈｃｙ对冠心病患者的影响主要在男性可能更明显。Objective: To examine homocysteine (Hcy)levels in patients with coronary heart disease. Methods: Plasma Hcy levels of 209 patients and 101 normal controls were determined by high pressure liquid chromatography. Results: Plasma Hcy levels in the patients (23. 42 ± 26. 87μmol/L)were higher than those in the controls (14 .98 ± 13 .05 μmol/L). More cases of hyperhomocysteiemia (47. 5) %were found in the patients than in the controls (20 .6% ). Hcy levels in male patients (24.85 ± 28.38 μmol/L)were significantly higher than those in male controls (15.54 ±12.85μmol/L), but no difference was noted between female patients and female controls. Total Hcy levels in patients with acute myocardial infarction were higher than those with pectoris. There was a trend of increased Hcy levels in patients with lesions of one, two or three vessels. Conclusion: Hcy level was significantly increased in Chinese patients with coronary heart disease.The incidence of hyper- homocysteinemia was higher.The effect of homocysteine was more obvious the male patients.

关 键 词：冠心病 同型半胱氨酸 临床特点 急性心肌梗塞 

分 类 号：R541.4[医药卫生—心血管疾病]