多巴酚丁胺对硬膜外阻滞后低血压时血流动力学影响  

EFFECT OF DOBUTAMINE ON HEMODYNAMICS DURING EPIDURAL BLOCK HYPOTENSION IN CANINES

作　　者：徐国辉[1] 庄心良[1] 李士通[1] 王珍娣[1] 陆惟俊[1] 

机构地区：[1]上海市第一人民医院麻醉科,上海200080

出　　处：《河北医科大学学报》2001年第5期283-286,共4页Journal of Hebei Medical University

摘　　要：目的观察多巴酚丁胺对硬膜外阻滞后低血压时的血流动力学影响。方法犬硬膜外阻滞后低血压时 ,静脉滴注 5或 10 μg/kg多巴酚丁胺药液 ,观察用药后 5和 10min时对全身血流动力学和肝肾血流量的影响 ,心输出量、肝肾血流量均用电磁血流量仪直接测定。结果两组药量静脉滴注后平均动脉压和外周血管阻力均未恢复到阻滞前水平 ;对肾血流量无明显影响 ,肝血管阻力较阻滞后增加 ,但仍低于阻滞前水平。结论本文剂量的多巴酚丁胺对硬膜外阻滞后血流动力学影响较小。ObjectiveTo study the effect of dobutamine on hemodynamics during epidural block hypotension.MethodsA moderate hypotension was induced in 18 mongrel dogs with epidural block.Dobutamine 5 or 10 μg/kg was administered intravenously to treat the hypotension.Hemodynamic parameters such as cardiac output,hepatic and renal blood flow were measured at 5 and 10 minutes after dobutamine infusion by electromagnetic flowmeters.Blood pressure and heart rate were also observed simultaneously.ResultsDobutamine infusion at the rate of 5 μg/kg did not cause any changes in parameters observed after 5 and 10 minutes. With 10 μg/kg of dobutamine,only mean arterial pressure(MAP) and systemic rascular resistance(SVR) increased significantly at 10 minutes after infusion when compared with the value after epidural block,but they could not return the baseline.There were no significant changes in hepatic and renal blood flow at 5 and 10 minutes after dobutamine.ConclusionDobutamine infusion at the rate of 5 or 10 μg/kg did not cause any significant changes in hemodynamics during epidural hypotension. MeSH dobutamine/drug eff;anesthesia,epidural/adv eff;hypotension;hemodynamics;dog

关 键 词：多巴酚丁胺 药物作用 硬膜外麻醉 副作用 低血压 血液动力学 

分 类 号：R544.2[医药卫生—心血管疾病] R614.42[医药卫生—内科学]