肺炎衣原体肺炎发病机制的初步实验研究  

Experimental study on the pathogenesis of chlamydia pneumoniae strain pneumonitis

作　　者：施毅[1] 印洁[1] 詹化文[2] 苏欣[1] 夏锡荣[1] 周晓军[2] 申萍[1] 

机构地区：[1]南京军区南京总医院呼吸科,210002 [2]南京军区南京总医院病理科,210002

出　　处：《江苏医药》2001年第9期670-672,共3页Jiangsu Medical Journal

基　　金：江苏省科委自然科学基金应用基础研究计划资助 (编号 :BJ980 6 5 )

摘　　要：目的　初步探讨肺炎衣原体肺炎的发病机制。方法　以肺炎衣原体鼻内或静脉接种Icr小鼠 ,通过不同时点 (6 0天内 )处死动物 ,观察其肺部的病理改变。结果　鼻内接种肺炎衣原体后 ,Icr小鼠可以产生肺部感染 ,特征性病理改变是斑片状间质性肺炎 ,早期 (7天以内 )病变较重 ,以嗜中性粒细胞浸润为主 ,并伴有泡沫细胞堆积 ;后期 (14天以后 )病变开始减轻 ,以嗜中性粒细胞和淋巴细胞混合浸润为主 ,并逐渐转为以淋巴细胞浸润为主。静脉接种后的肺部改变与鼻内接种类似 ,但病变程度要轻得多 ,两者的差别在发病早期更为明显。结论　给Icr小鼠接种肺炎衣原体可以产生以间质性肺炎为特征的肺部感染 ,鼻内接种者更为明显。Objective We used mice as experimental animals for C.pneumoniae infection and studied the pathogenesis of C.pneumoniae pneumonitis.Methods Intranasal or intravenous inoculation of Icr mice with C.pneumoniae induced a prolonged course of lung infection,as demonstrated by persistence of lung pathology(60 days).Results The Icr mice were shown to be susceptible to C.pneumoniae.In the intranasal inoculation of mice,the lung pathology was characterized by patchy interstitial pneumonitis with predominantly neutrophil leukocyte infiltration in the early(7 days) and lyphocytes infiltration in the later stages(14 days later)of infection.After iv inoculation,a similar interstitial pneumonitis was seen,but it was milder and more patchy,especially in the early stages.Conclusions The Icr mice are susceptible to C.pneumoniae and the pulmonary infection is characterized by interstitial pneumonitis,especially in mice of intranasal inoculation.

关 键 词：肺炎衣原体肺炎 呼吸道感染 发病机制 实验研究 

分 类 号：R563.1[医药卫生—呼吸系统]