齿龈内阿米巴致病作用的动物实验  

Experimental Study on the Pathogenesis of Entamoeba gingivalis

作　　者：刘光英[1] 陈金富[1] 温旺荣[2] 陈文列[3] 林立群4 洪航[5] 

机构地区：[1]福建医科大学寄生虫学教研室,福州350004 [2]福建医科大学临床微生物学教研室,福州350004 [3]福建医科大学电子显微镜室,福州350004 [4]福建医科大学 [5]福州市第一医院口腔科,福州350009

出　　处：《中国寄生虫学与寄生虫病杂志》2001年第4期229-232,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：福建省科委资助课题 (编号 95 -J-33)&&

摘　　要：目的　研究齿龈内阿米巴 (Entamoeba gingivalis,E.g.)的致病作用及其与牙周病的关系。　方法　大鼠经免疫抑制剂处理 1wk,并于切牙颈部结扎钢丝后 ,随机分为 3组 ,分别于龈缘涂抹 E.g.、共生菌 (symbioticbacteria,s.b.)及生理盐水 ,观察各组大鼠牙周组织发病情况 ,并查脓液中有无活的病原体。　结果　 E.g.组大鼠牙周组织发病率高于 s.b.组和对照组 (P<0 .0 5 ) ,s.b.组大鼠发病率亦高于对照组 (P<0 .0 5 ) ,脓液镜检或经培养均查见相应的病原体。　结论　齿龈内阿米巴是一种条件致病病原体 ,当宿主免疫力下降时 。Objective To study the pathogenesis of Entamoeba gingivalis ( E\^g .) and its relation to periodontal diseases.\ Methods Rats were treated with immuno\|inhibitor for one week and the neck of incisor teeth of the rats was bound with steel wire. They were randomly divided into three groups: the first group was infected by E\^g . in the periodontal tissue, the second group was infected by symbiotic bacteria (s.b.),and the third group was given physiological saline as control.Observation on the periodontal inflammation was made for each group of rats, and the purulent secretion from periodontal abscess was examined for living pathogens.\ Results The incidence of periodontal diseases in rats infected by E\^g . was higher than that of symbiotic bacteria group and that of control ( P <0\^05), the incidence of periodontal diseases in rats infected by s.b. was higher than that of control group ( P <0\^05). Living pathogens were found in the abscess liquid.\ Conclusion E\^g . is an opportunistic pathogen, which, together with synergistic symbiotic bacteria, can cause periodontal diseases in hosts with low immunity.

关 键 词：齿龈内阿米巴 共生菌 致病作用 牙周病 实验研究 

分 类 号：R531.1[医药卫生—内科学] R781.4[医药卫生—临床医学]