抗杀菌渗透性增强蛋白抗体的临床意义  

Clinical significance of anti-bactericidal/permeability increasing protein autoantibodies

作　　者：孙奇志[1] 赵明辉[1] 

机构地区：[1]北京大学第一医院肾内科,100034

出　　处：《中国实用内科杂志》2001年第9期529-530,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的　评价抗杀菌渗透性增强蛋白抗体 (BPI)临床意义。方法　应用纯化的BPI抗原 ,以酶联免疫吸附方法 (ELISA)检测 410份病人血清抗BPI抗体 ,免疫印迹法验证部分阳性血清 ,分析临床资料。结果　 47例抗BPI阳性。临床肺部疾病 18例 ,包括 10例慢性支气管炎 ;7例系统性红斑狼疮 ;5例溃疡性结肠炎 ;3例原发性小血管炎及其它。肺部炎症病变及血管炎的 2 1例病人中 9人合并呼吸道绿脓肝菌感染。结论　抗BPI自身抗体可见于慢性肺部炎症性疾病和自身免疫性疾病 ,其临床意义有待于进一步阐明。Objective\ To evaluate the clinical value of anti-bactericidal/permeability increasing protein(BPI)antibody.Methods\ 410 consecutive sera,sent for routine ANCA testing from hospitalized patients were screened in an anti-BPI ELISA using lightly purified BPI as solid-phrase ligand.Some strong positive sera were also tested by Western blot analysis using neutrophil granule proteins as antigens.The clinical significance of the anti-BPI antibody positive patients were analysed.Results\ 47/410 sera were positive for anti-BPI antibodies,including 18 patients with pulmonary diseases,10 with chronic bronchitis,7 with systemic lupus erythematosus,5 with ulcer colitis,3 with primary small vessel vasculitis and others.Among 21 with pulmonary inflammatory lesions and vasculitis patients,there were 9 with respiratory tract pseudomonas aeruginosa infection.Conclusions\ Anti-BPI antibodies could be detected in some chronic pulmonary inflammatory diseases and some autoimmune diseases.The clinical significance of anti-BPI antibodies need to be further investigated.

关 键 词：杀菌渗透性增强蛋白 抗中性粒细胞浆抗体 自身免疫 抗体 血管炎 临床意义 

分 类 号：R543[医药卫生—心血管疾病]