盐酸川芎嗪对大鼠在体鼻粘膜吸收研究  

Study on Nasal Mucosa Absorption in Vivo of Tetramethylpyrazine Hydrochloride in Rats

作　　者：龚志南[1] 徐莲英[1] 宋经中[1] 马树人[2] 陶建生[1] 

机构地区：[1]上海中医药大学,上海200032 [2]华东理工大学化学系,上海200237

出　　处：《中成药》2001年第6期394-396,共3页Chinese Traditional Patent Medicine

基　　金：上海市教委发展基金! (99C11)

摘　　要：目的 :研究盐酸川芎嗪的鼻粘膜吸收特性。方法 :采用盐酸川芎嗪进行鼻腔灌流实验。结果 :随着盐酸川芎嗪的浓度增加 ,其吸收速度呈剂量依赖性增加 ;在 pH值 4.70～ 7.0 0范围内 ,随pH值的升高 ,其吸收速度逐渐增加。 结论 :盐酸川芎嗪鼻腔灌流液的 pH为 7.0 0时 。Objective: To investigate the characteristic of nasal mucosa absorption in vivo of tetramethylpyrazine hydrochloride (TMP HCl) in rats. Methods: The nasal circulatory perfusion test of TMP HCl was performed in rats.Results: The absorption rate constants was increased with the increasing of the concentration of TMP HCl; The absorption rate constants was increased with the elevating of pH values at the pH value range of 4.70～7.00. Conclusion:When the pH value of nasal circulatory perfusion liquid of TMP HCl is 7.00, the nasal mucosa absorption is optimal.

关 键 词：盐酸川芎嗪 鼻腔循环灌流 鼻粘膜吸收 吸收速度常数 大鼠 

分 类 号：R287[医药卫生—中药学] R285[医药卫生—中医学]