温病气分证与微观血瘀相关性的实验研究  

EXPERIMENTAL STUDY ON THE RELATIVITY BETWEEN QIFEN SYNDROME AND MICROCOSMIC BLOOD STASIS IN SEASONAL FEBRILE DISEASE

作　　者：沈庆法[1] 杨爱东[1] 

机构地区：[1]上海中医药大学,上海200032

出　　处：《中国中医药科技》2001年第4期209-210,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：上海市卫生局资助项目No 97CJ0 3

摘　　要：目的 :探讨温病气分证与微观血瘀的相关性。方法 :实验采用大肠杆菌内毒素从家兔耳缘静脉注射造成温病气分证模型 ,观察模型组病理学、血液流变学、凝血指标、细胞因子 (TNF -α、IL - 6、IL - 8)水平的改变。结果 :模型组光镜下肺脏有微血栓存在 ,且模型动物出现血液流变学及凝血指标异常 ,模型组家兔血浆TNF -α、IL - 6、IL - 8水平均较正常组升高 ,升高水平与脏器组织的损害程度一致。结论 :温病气分证存在微观血瘀。TNF -α所导致的炎症级联反应 (TNF-α→Ⅱ - 6→IL - 8)可能是温病气分证微观血瘀形成的原因之一。Objective:To observe the the mechanism of relativity between Qifen syndrome and microcosmic blood stasis in seasonal febrile disease(SFR).Method: Qifen syndrome in SFR model was induced by colibacillary endotoxin via auricular intravenous injection.The change on pathomorphology,blood rheology,cruor indexes,and Cytokines TNF-α,IL-6,IL-8 in the model was observed. Result:it showed the existence of microthrombus in the lung via microscope in the model,it also indicated that the abnormality of blood rheology and cruor indexes,TNF-α,IL-6 and IL-8 levels increased in model group,which were confirmed with obvious damage of tissue or organ damage.

关 键 词：温病气分证 病理学 血瘀 血液流变学 肿瘤坏死因子 

分 类 号：R254[医药卫生—中医内科学]