三种促超排卵方案体外受精-胚胎移植临床妊娠率的分析  

Analysis of the clinical pregnancy rate of in vitro fertilization and embryo transfer with three tropic hyperovulation programmes.

作　　者：张慧琴[1] 邓晓惠[1] 于红玲[1] 闫旻[1] 孔北华[1] 江森[1] 杜丽娟[1] 洪凡真[1] 

机构地区：[1]山东大学齐鲁医院妇产科,济南250012

出　　处：《现代妇产科进展》2001年第4期288-290,共3页Progress in Obstetrics and Gynecology

基　　金：国家教育部归国人员科研基金资助项目 (EJ980 131)

摘　　要：目的 :分析 3种促超排卵方案 (tropichyperovulationprogramme ,THOP)体外受精 -胚胎移植 (IVF -ET)的临床妊娠率。方法 :不孕症 136例分为 3组 :1组 5 1例 ,应用高纯促卵泡成熟激素 (HP -FSH ,商品名Metrodine -HP) ,递减给药促超排卵 ,应用促性腺激素释放激素兴奋剂 (GnRH -a ,商品名Buserelin)长方案降调节 ,从月经第 3天开始递减HP-FSH。 2组 5 0例 ,HP -FSH和人绝经期促性腺激素 (hMG)联合递减给药的促超排卵长方案降调节。 3组 35例 ,hMG递增给药促超排卵。分析 3种THOP的平均取卵数、受精后卵裂数、移植数、临床妊娠数及IVF -ET移植周期的临床妊娠率。结果 :(1) 1组 ,平均取卵数 10 .13± 4 .4 9,卵受精数 7.83± 4 .13,受精率 77.2 9% ,卵裂数 7.6 2± 4 .19,移植数3.88± 1.17及临床妊娠数 18,临床妊娠率 35 .2 9% ;(2 ) 2组 ,平均取卵数 9.16± 5 .4 9,卵受精数 6 .84± 4 .2 3,受精率 74 .6 7% ,卵裂数 6 .5± 4 .2 2 ,移植数 3.6 8± 0 .99及临床妊娠数15 ,临床妊娠率 30 .0 % ;(3) 3组 ,平均取卵数 11.31± 7.6 4 ,卵受精数 7.89± 5 .36 ,受精率 6 9.82 % ,卵裂数 7.75± 5 .94 ,移植数 3.6 8± 1.0 8及临床妊娠数 15 ,临床妊娠率4 2 .86 %。 1组与 2组用药安瓿比较 ,差异有高度显著性Objective:To determine on the clinical pregnancy rate of in vitro fertilization and embryo transfer (IVF-ET) with three tropic hyperovulation programmes(THOP).Methods:136 cases with sterility were performed with three THOP for IVF-ET and divided into 3 groups:Group 1(n=51),high-purified follicle-stimulating hormone (HP-FSH,goods name:Metrodine) decreased progressively for tropic hyperovulation and GnRH-a (goods name:Buserelin) was used for long programme and down regulation.HP-FSH was decreased progressively from the 3rd day of menstruation.Group 2(n=50),HP-FSH+hMG were combined to decrease progressively for long programme and down regulation for tropic hyperovulation.Group 3(n=35),hMG was used to increase progressively for tropic hyperovulation.The three programmes of tropic hyper ovulation were analysed for the average number of ova obtained,fertilized cleavage of oocytes,implantation,and number of clinical pregnancy,clinical pregnancy rates in IVF-ET cycles.Results:Group 1,average number of ova obtained was 10.13±4.49,number of fertilized ova 7.83±4.13,rate of fertilization 69.82%,number of cleavage 7.75±5.94,number of transferred embryos 3.68±1.08,and number of cleavage 7.62±4.19,number of transferred embryos 3.88±1.17,and number of clinical pregnancy 18,clinical pregnancy rate 35.29%.Group 2,average number of ova obtained was 9.16±5.49,number of fertilized ova 6.84±4.23,rate of fertilization 74.67%,number of cleavage 6.5±4.22,number of transferred embryos 3.68±0.99,and clinical pregancy 15,clinical pregnancy rate 30.0%.Group 3,average number of ova obtained was 11.3±7.64,number of fertilized ova 7.89±5.36,rate of fertilization,77.29%,number of clinical pregnancy 15,clinical pregnancy rate 42.86%,drug used in group 1 and group 2,there was signifiant difference in drug used in group 1 and group 2 (P<0.01),in group 2 vs group 3,there was significant difference too.In the three groups of clinical pregnancy rates of IVF-ET,there were no statistical difference among dinical pregnancy rates of IVF-ET

关 键 词：体外受精 胚胎移植 促超排卵 妊娠率 

分 类 号：R321.3[医药卫生—人体解剖和组织胚胎学]