2型糖尿病患者血小板α颗粒膜蛋白、纤维蛋白原和D-二聚体的检测及意义  

Determination of Concentration of Plasma GMP-140,Fibrinogen and D-Dimer in type 2 Diabetes Mellitus and Its Clinical Significance

作　　者：席刚[1] 陆彤[1] 刘芳[1] 侯东哲[1] 李毅[1] 肖淑珍[1] 

机构地区：[1]天津市环湖医院内科,天津300060

出　　处：《中国慢性病预防与控制》2001年第4期165-166,共2页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨糖尿病患者血小板 α颗粒膜蛋白 (GMP- 140 )、纤维蛋白原 (Fg)及 D-二聚体 (D- D)血浆含量对血管并发症的影响。方法将 6 9例 2型糖尿病患者分成两组 ,一组 (35例 )有血管并发症 ,另一组 (34例 )无血管并发症。对每个患者进行血浆 GMP- 140、Fg及 D- D含量的测定 ,并与 30例健康人进行对照。结果糖尿病组患者无论有无血管并发症 ,血浆 GMP- 140、Fg及 D- D均高于正常对照组 (P均 <0 .0 1)。血管并发症组与无血管并发症组相比 ,上述指标升高更为显著 (P均 <0 .0 1)。结论 2型糖尿病患者血液处于高凝状态 ,血小板功能异常 ,并存在继发性纤溶亢进。测定血浆 GMP- 140、Fg及 D- D有助于早期发现血栓前状态及血管病变以指导临床早期干预治疗。Objective To evaluate the significance of plasma concentrations of α granule membrane protein(GMP 140),fibrinogen(Fg) and D Dimer(D D) in type 2 diabetes mellitus.Methods Sixty nine diabetic patients were divided into two groups:one group(35 cases) with angiopathy and the other group (34 cases) without angiopathy.The plasma concentrations of GMP 140,Fg and D D were determined in each patients.Thirty health individuals were served as controls.Results The concentrations of GMP 140,Fg and D D in both groups were significantly higher than those in controls( P <0.01).These concentrations in the group with angiopathy were significantly higher than those in group with non angiopathy( P <0.01).Conclusion Type 2 diabetes mellitus was in hypercoagulable.The activity of platelet and ability of fibrinolysis were increased.Determination of plasma concentrations of GMP 140,Fg and D D may contribute to early found thrombosis and angiopathy occurrence,which indicate clinical interference treatment in early stage.\;

关 键 词：Ⅱ型糖尿病 血管病变 血小板Α颗粒膜蛋白 纤维蛋白原 D-二聚体 

分 类 号：R587.1[医药卫生—内分泌]