安宫黄体酮肟合成方法的改进  

Improved Synthesis of Medroxy Progester one Oxime Acetate

作　　者：马臻[1] 王尊元[1] 朱家蕙[1] 沈正荣[1] 

机构地区：[1]浙江省医学科学院药物研究所,浙江杭州310013

出　　处：《中国药物化学杂志》2001年第4期229-229,232,共2页Chinese Journal of Medicinal Chemistry

摘　　要：报道了改进的安宫黄体酮肟合成方法。用毒性较小的乙酸钠作催化剂 ,安宫黄体酮与盐酸羟胺缩合而成 ,收率为 84 6%An improved synthesis of medroxy progesterone oxim e acetate was reported.Using sodium acetate as a catalyst,the title compound was obtained by the reaction of medroxy progesterone acetate and hydroxylamine hydro chloride in the yield of 846%.

关 键 词：安宫黄体酮 酮肟 合成 

分 类 号：TQ463[化学工程—制药化工]