多巴酚丁胺负荷试验中多普勒组织成象评价冠心病左室整体舒张功能  

Application of Doppler tissue imaging to assessment of global diastolic function of left ventricle in coronary artery disease during dubitamine stress

作　　者：李楠[1] 钱蕴秋[1] 张军[1] 周晓东[1] 朱永胜[1] 吴巧英[1] 李寰[2] 

机构地区：[1]第四军医大学西京医院超声诊断科,陕西西安710032 [2]第四军医大学西京医院心内科,陕西西安710032

出　　处：《心脏杂志》2001年第4期271-273,共3页Chinese Heart Journal

摘　　要：目的 :探讨多巴酚丁胺 (DBA)负荷中多普勒组织成象 (DTI)检测冠心病患者左室整体舒张功能的变化。方法 :冠心病患者 30例 ,正常人 18例 ,按 5 m in递增法以 5 ,10 ,15 ,2 0 ,30 μg· kg- 1· min- 1浓度静注 DBA,DTI记录注药前及每一剂量级时二尖瓣环运动情况。结果 :正常组注药后 Ea增加明显 ,但 Ea/ Aa略有下降 ,无显著差异。单支病变组 Ea升高不显著。Ea/ Aa则明显减低。多支病变组 Ea,Ea/ Aa均显著减低。单支病变组、多支病变组 Ea/ Aa注药前、后均低于正常组 ,差异显著。且注药前、后二尖瓣平均舒张速度变化率 Δ Ea%及 ΔEa/ Aa%显著低于正常组。结论AIM:To evaluate the application of Doppler tissue imaging (DTI) with dubitamine(DBA) stress echocardiography to assessment of global diastolic function of left ventricle for detection of coronary artery disease (CAD). METHODS:30 patients with CAD and 18 subjects of normal control group underwent dubitamine stress echocardiography,and they were given addied doses of 5,10,15,20,30 μg·kg -1 ·min -1 per 5 minutes, and their velocities of mitral valve annular were measured by DTI. RESULTS:Ea increased significantly and Ea/Aa decreased a little but not significantly in the control group after dubitamine injection. Ea increased insignificantly and Ea/Aa decreased significantly in the group with single coronary artery branch stenosis. Both Ea and Ea/Aa decreased significantly in the group with more than one coronary artery branches stenosis. Ea,Ea/Aa,ΔEa% and ΔEa/Aa% in the two CAD groups were all significantly lower than those of the control group either before or after the medication. CONCLUSION:Velocities of mitral valve annular were measured by DTI and can be used to assess global diastolic function of the left ventricle during dubitamine stress test.

关 键 词：冠状动脉疾病 多普勒组织成像 多巴酚丁胺负荷试验 超声心动描记术 左室整体舒张功能 

分 类 号：R541.4[医药卫生—心血管疾病]