奥沙普秦体外渗透性的研究  

Study on the in vitro permeability of oxaprozin

作　　者：郭宏[1] 邱树勇[1] 侯景刚[2] 胡建平[3] 潘卫三[3] 

机构地区：[1]佳木斯大学药学系,佳木斯154002 [2]沈阳药业股份有限公司,沈阳110015 [3]沈阳药科大学药剂教研室,沈阳110015

出　　处：《中国新药杂志》2001年第8期601-602,共2页Chinese Journal of New Drugs

摘　　要：目的 :研究不同促渗剂对奥沙普秦渗透性的影响。方法 :采用Valia Chien扩散池进行大鼠离体皮肤的体外渗透实验。结果 :1%氮酮、3%氮酮、10 %油酸均具有极显著的促渗作用 (P <0 .0 1) ,5 %油酸具有显著的促渗作用 (P <0 .0 5 ) ,而薄荷油的促渗作用不明显 (P >0 .0 5 ) ,其中以 3%氮酮的促渗效果最好。结论 :奥沙普秦经皮渗透符合零级动力学过程 。Objective:To study the effect of osmotic enhancers on the permeability of oxaprozin.Methods:The penetrating rate of oxaprozin to pass the isolated skin of rats was measured by using Valia Chien diffusion cell.Results:1% and 3% azone,and 10% oleic acid possess very remarkable osmotic enhancer's effect,and 5% oleic acid also has remarkable osmotic enhancer's effect.3% azone is the best osmotic enhancer in comparison with the others.Conclusion:The transdermal process of oxaprozin fitted to a zero order kinetic mechanism and was not affected by addition of osmotic enhancer. [

关 键 词：奥沙普秦 透皮吸收 促渗剂 

分 类 号：R971.1[医药卫生—药品]