区域动脉灌注给药治疗重症急性胰腺炎  

Local arterial infusion of medicine in the treatment of severe acute pancreatitis

作　　者：李占武[1] 史光军[1] 胡义利[1] 赵宜仁[1] 

机构地区：[1]青岛大学医学院附属青岛市立医院肝胆外科,山东青岛266011

出　　处：《中国普通外科杂志》2001年第4期299-301,共3页China Journal of General Surgery

摘　　要：目的　探讨区域动脉灌注给药在重症急性胰腺炎 (SAP)治疗中的作用。方法　回顾性分析 1982年 2月～ 2 0 0 0年 8月收治的SAP 85例的临床资料 ,并按不同阶段的治疗方法分为 3组 :A组 ,1982年 2月～ 1993年 12月以手术治疗为主 ,42例 ;B组 ,1994年 1月～ 1996年 8月以周围静脉给药治疗为主 ,2 3例 ;C组 ,1996年 9月～ 2 0 0 0年 8月采用持续区域动脉灌注 (LAI)给药为主 ,2 0例。结果　A组继发感染率 47 6 % (2 0 / 42 ) ,病死率35 7% (15 / 42 ) ;B组继发感染率 2 6 1% (6 / 2 3) ,病死率 2 1 7% (5 / 2 3) ;C组继发感染率10 0 % (2 / 2 0 ) ,病死率 5 0 % (1/ 2 0 )。C组继发感染率 ,病死率与A ,B组相比差异均有显著意义 (P <0 .0 1〉。Objective To evaluate the effect of local arterial infusion (LAI) of medicine on the treatment of servere acute pancreatitis(SAP). Methods The clinical data of 85 cases of SAP were retrospectively analyzed, and divided into three groups according to the admitted time:Group A. 42 cases admitted from February 1982 to December 1993,treated mainly by operation. Group B. 23 cases, admitted January 1994 to Auguest 1996, treated mainly by non operation. Group C. 20 cases, from September 1996 to Auguest 2000. treated mainly by LAI. Results The secondary infection rate in group A, B and C were 47%(20/42),26%(6/23) and 10%(2/20) respectively. The mortality in group A ,B and C were 36%(15/42),22%(5/23) and 5%(1/20),respectively. The difference in the secondary infection rate and mortality between group A , B and group C showed obvious significance (P<0.01). Conclusions Local arterial infusion of medicine is superior to surgery or intravenous administration of medicine for patient with SAP.

关 键 词：胰腺炎 药物疗法 局部灌注 动脉内输注 治疗 

分 类 号：R657.510.5[医药卫生—外科学]