阿仑膦酸钠对骨小梁结构特性的作用  

Effects of alendronate on trabecular bone structural properties

作　　者：胡建华[1] 黄公怡[1] 丁铭 

机构地区：[1]北京医院骨科,100730 [2]丹麦Aarhus大学医院骨科

出　　处：《中华骨科杂志》2001年第9期529-532,共4页Chinese Journal of Orthopaedics

摘　　要：目的评价阿仑膦酸钠对骨小梁结构特性的作用。方法选取成年雌性Hound犬16只,随机分成两组:实验组8只,口服阿仑膦酸钠,剂量为0.5mg·kg-1·d-1;另选8只作为对照组。12周后处死16只犬并收集其L1和L2标本。直接从三维图像计算腰椎结构参数。结果实验组在服用阿仑膦酸钠后其L1和L2骨小梁体积分数各增加9.5%和7.7%,骨小梁厚度显著增加,但骨小梁间距保持恒定。与对照组相比,实验组骨小梁各向异性下降,骨表面积/体积比率显著降低,而骨表面密度增高。结论口服阿仑膦酸钠,剂量为时0.5mg·kg-1·d-1,短期内治疗能增强犬科骨小梁的结构特性。故阿仑膦酸钠短期内有增强健康骨小梁结构特性的作用。Objective To evaluate alendronate with regards to its effect s on trabecular bone structural properties. Methods Alendronate was administered at a daily p.o. dose of 0.5 mg·kg－1·d－1 over a 12 weeks period in Hound do gs (n=8 ＋ 8 for control and treated group), the structural indices of the lumba r vertebral (L 1 and L 2) trabecular bone were assessed directly from 3 D image s. Results Treatment with alendronate increased bone volume fraction by 9.5％ a nd 7.7％ respectively, in the L 1 and L 2. Trabecular thickness significantly in creased after alendronate treatment, whereas trabecular separation remained cons tant. The degree of anisotropy for the alendronate treated group was decreased compared with that of the control group. Bone surface to volume ratio declined s ignificantly in the alendronate treated group, whereas alendronate induced a hi gher value of bone surface density. Conclusion Alendronate increased the struct ural properties of canine trabecular bone after short-term treatment at a dose of 0.5 mg·kg－1·d－1. Thus, alendronate could increase the structural properti es of healthy trabecular bone in a short-term period.

关 键 词：二膦酸盐类 骨组织 骨密度 骨小梁 

分 类 号：R68[医药卫生—骨科学]