依那普利对高血压患者左心室质量指数的逆转观察  

Effect of enalapril on regression of left ventricular mass index in hypertensives

作　　者：刘勇[1] 陈家香[2] 陈运贞[2] 王志华[2] 廖卉[2] 罗素新[2] 

机构地区：[1]四川省自贡市第三人民医院心内科,643020 [2]重庆医科大学附属第一医院

出　　处：《中国全科医学》2001年第6期441-442,共2页Chinese General Practice

摘　　要：目的　观察依那普利治疗前后对左心室肥厚或增重的逆转作用和这种作用可能开始有显著性的最短时间。方法　用彩色超声心动图检查计算 30例高血压患者自身前后配对的左心室质量指数 (LVMI)变化。结果　治疗后全组LVMI由 (117 5 8± 2 0 49)g/m2 降为 (10 6 80± 15 6 7)g/m2 (P <0 0 0 5 ) ,逆转率为 9 2 % ;其中肥厚亚组由 (143 88± 11 38)g/m2 降为 (119 38± 12 91)g/m2 (P <0 0 0 5 ) ,逆转率为 17 0 % ;降压有效亚组由 (119 6 9± 2 2 84) g/m2 降为 (10 5 41± 17 0 6 ) g/m2 (P <0 0 0 1) ,逆转率为 12 0 %。结论　依那普利 5～ 6周降压治疗同时 ,可显著地逆转高血压病人的左心室肥厚或增重 ,且左心室肥厚或增重越明显、降压越有效者 ,其逆转的显著性越强 ;结合文献推测 5～ 6周可能是其逆转左心室肥厚或增重开始达显著性差异的最短时间。Objective To observe the effect of treatment with enalapril on left ventricular mass index(LVMI) in essential hypertesion(EH).Methods Color echocardiographic measurement of LVMI were performed pre-and-post treatment with enalapril in 30 cases with hypertension.Results Pre versus post treatment LVMI were(117 58±20 49) versus(106 80±15 67)g/m 2(P<0 005),the reversal rate was 9 2%;In LV hypertrophic subgroup(n=8),and BP reduced effectively subgroup (n=18) were 143 88±11 38 versus 119 38±12 91(P<0 005),the reversal rate was 17%,and 119 69±22 84 versus 105 41±17 06(P<0 001),the reversal rate was 12% respective-ly.Conclusions (1)Enalapril could induce significantly regression of LVH or LV overweight after 5～6 weeks,moreover,the more LV hypertrophic and BP effective,the more regressive.(2)The time of 5～6 weeks may be the shortest period of enalapril-induced LVMI obvious regression.

关 键 词：高血压病 左心室肥厚 左心室质量指数 依那普利 LVH 超声心动检查 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]