慢乙肝病人尿中转化生长因子-β_1水平测定的意义  

The significance of urine transforming growth factor-β_1(TGF-β_1)and serum procollagen type Ⅲ(PCⅢ),collagen type Ⅳ(Ⅳ-C), hyaluronic (HA) and laminin(LN)in patient with chronic HBV related liver disease

作　　者：李清华[1] 李辉[1] 秦成勇[2] 韩国庆[2] 

机构地区：[1]青岛市立医院消化内科,山东青岛266011 [2]山东省立医院消化内科,山东济南250021

出　　处：《临床肝胆病杂志》2001年第3期161-162,共2页Journal of Clinical Hepatology

摘　　要：研究和探讨检测尿TGF - β1水平在肝纤维化中的意义。采用双抗体夹心ELISA法及放射免疫法检测了 15例正常人 ,15例慢活肝和 15例肝硬化患者尿TGF - β1水平 (用同一尿标本Cr水平作标准比 )和血清PCⅢ ,Ⅳ -C ,HA及LN水平。肝硬化患者尿TGF - β1/Cr水平和PCⅢ ,Ⅳ -C ,HA及LN水平明显高于慢活肝和正常人组 ,且两者呈明显正相关。另外尿TGF - β1/Cr水平与肝功能指标中白蛋白呈明显负相关 ,与球蛋白、间接胆红素呈明显正相关。尿TGF - β1/Cr水平与肝纤维化密切相关 。To examine urine transforming growth factor-β 1 concentration so as to ascertain the significance in hepatic fibrosis. Urine TGF-β 1 concentration and the level of serum PCⅢ,ⅣC,HA and LN were detected by sandwich enzymelinked immunosorbent assay (ELISA) and radioimunoassay (RIA) from 15 patient with chronic active hepatitis B and 15 with cirrhosis.The levels of urine TGF-β 1/Cr and serum PCⅢ,ⅣC,HA,LN in patients with cirrhosis were higher than those of chronic active hepatitis and normal group.Between them existed a positive correlation P<0.05 or P<0.01).And urine TGF-β 1/Cr also showed a positive relationship with globulin and indirect bilirubin (IBil)(P<0.05),but a negative with albumin (P<0.05).Higher urine TGF-β 1/Cr levels correlate with more severe hepatic fibrosis.So it may be used as a useful marker for hepatic fibrogenesis.

关 键 词：转化生长因子Β1 肝纤维化 尿 TGF-Β1 临床检测 ECM 慢性乙型肝炎 

分 类 号：R512.62[医药卫生—内科学]