益肾降浊汤对脑缺血再灌注大鼠海马组织超微结构的影响  

Effect of YishenJiangzhuo decoction on the ultrastructure of hippocampal by cerebral ischemia reperfusion in rats

作　　者：高维娟[1] 黄启福[2] 贾旭[2] 

机构地区：[1]承德医学院科研处,河北承德067000 [2]北京中医药大学病理学教研室,北京100029

出　　处：《河北医学》2001年第8期682-684,共3页Hebei Medicine

摘　　要：目的 :观察益肾降浊汤对大鼠脑缺血再灌注后海马组织超微结构的影响。方法 :对大鼠进行双侧颈总动脉缺血再灌注 ,于术后第 1、7、15d取海马电镜制样、观察。结果 :模型大鼠术后 1d神经细胞内线粒体肿胀、嵴断裂 ,空泡样变 ;7d神经元变性、核碎裂或皱缩 ;15d有胶质细胞增生。治疗组脑组织的损伤性变化明显轻于模型组。结论 :益肾降浊汤可明显减轻脑缺血再灌注后的神经元损伤 ,对神经元有保护作用。Objective: To observe the effect of YishenJiangzhuo decoction on the ultrastructure of hippocampal by cerebral ischemia reperfusion in rats. Methods: Cerebral ischemia reperfusion was performed by means of occluding common carotid artery of rat. The hippocampal was extracted to be made specimen for observing by electron microscope on 1 th ?7 th and 15 th day postoperation. Results: It was found mistochondrial swelling, crest breaking and vacuolar degeneration in the nerve cell of model rat on the day, and found neuron degeneration, karyorrhexis or karyopyknosis on 7 th day. Gliocyte hyperplasia could be found on 15 th day. The damage change of hippocampal of the treated group was patently lighter than that of the model group. Conclusion: YishenJiangzhuo decoction could significantly reduce the neuron damage induced by cerebral ischemia reperfusion, and had the important effect on protecting the neurons.

关 键 词：益肾降浊汤 脑缺血再灌注 超微结构 神经元损伤 RND 

分 类 号：R277.7[医药卫生—中医学]