维生素E对慢性高原低氧大鼠心肌损伤的保护作用——光镜及电镜研究  

Protective Effects of Vitamin E on Myocardial Damages of Rats Exposed to High Altitude: A Light and Electron Microscopic Study

作　　者：段德义[1] 王扬宗[1] 

机构地区：[1]兰州医学院病理教研室

出　　处：《兰州医学院学报》1991年第2期68-71,共4页Journal of Lanzhou Medical College

摘　　要：本文用Wistar大鼠30只,随机分为实验组(20只,维生素E60mg/kg,隔日灌胃)和对照组(10只,等容积生理盐水灌胃),在6天内从海平面运至高原(3416米)进行实验。8周后,断头处死大鼠,留取心肌标本作光及电镜观察。结果发现:实验组光、电镜所见均明显比对照组轻;但两组肌细胞核及闰盘均未见明显异常,且两室病变程度无显著性差异。另外,慢性低氧大鼠Hb和RBC均明显比实验前高。30 Wistar rats weighing 182. 6±19. 4g were used and randomly divided into two groups: experimental group(20 rats,vitamin E 60mg · Kg^(-1)/2d,PO and control group(10 rats,the same volume of normal saline, PO). They were carried from sea level to high altitude(3,416m)by train within 6 days for experiment. The rats were killed decapitatedly after ex- pesure to high altitude for 8 weeks, and their heart tissue was left for histological and ultrastructural observation. The re- sults showed that in experimental group, light and electron microscopic findings were less severe than control group. How- ever, the nuclei and intercalated discs of the myocardia in both groups underwent no changes, and the degree of the my- ocardial alterations between two ventricles had no significant differences. The possible protective mechanisms of vitamin E were also discussed.

关 键 词：高原低氧 维生素E 心肌 光镜 电镜 

分 类 号：R594.302[医药卫生—内科学]