半肝切除手术对血清甲状腺激素、胰岛素水平的影响  

Effect of hemihepatectomy on the level of serum thyroxin and insulin

作　　者：尉继伟[1] 吉喆 计学理[1] 刘治帮[1] 周正忠[1] 李鹏[1] 耿建[1] 

机构地区：[1]北京铁路局大同中心医院普外科,山西大同037005

出　　处：《中国普通外科杂志》2001年第4期353-355,共3页China Journal of General Surgery

摘　　要：目的　研究左半肝切除引起的血清甲状腺激素、胰岛素变化。方法　手术切除兔左半肝 ,在空腹状态下分别于术前 1d ,术后 2 4h ,48h ,1周 ,1个月抽取外周静脉血 ,监测甲状腺激素、胰岛素。结果　术前TT3(1 93± 0 47)nmol/L ,TT4 (5 3 5 6± 8 4)nmol/L ;术后2 4hTT3,TT4 明显降低 ,术后 48h、术后 1周逐渐回升 ,TT3 较TT4 回升幅度大 ,术后 1个月二者接近术前水平。胰岛素术后明显升高 ,术后 1周开始下降 ,术后 1个月近术前水平。结论　肝切除术后出现正常甲状腺病态综合征或非甲状腺疾病综合征 ;Objective To study the mechanism of serum thyroxin and insulin change after hemihepatectomy. Methods The hemihepatectomy was performed in rabbits, the fasting peripheral blood samples were drawn on the day prior to surgery, and 24 hour, 48 hour, the first week, one month after operation respectively for monitoring the serum thyroxin and insulin.Results The level of TT 3 was (1.93±0.47) nmol/L, TT 4 (53.56±8.4) nmol/L preoperatively. The levels of TT 3 and TT 4 significantly decreased at 24 hour postoperatively, and gradually rose at 48 hour and up to normal levels in the first month postoperatively. The level of insulin rapidly rose immediately after operation, and began to decrease in the first week, and returned to the preoperative level in one month after operation. Conclusions The syndrome of normal thyroid disease and the syndrome of non thyroid disease can occur after hemihepatectomy; and hyperinsulinemia also can occur after hemihepatectomy.

关 键 词：肝切除术 代谢 甲状腺激素 血液 胰岛素 

分 类 号：R657.3[医药卫生—外科学]