米非司酮作用于兔输卵管收缩活动与Ca^（2＋）关系的研究  

A Study of the Relation between Ca￣(2+) and the Effect of Ru486 on Oviductal Contractility

作　　者：奚明[1] 扬丽珍[1] 谢衷明[1] 沈颖[1] 

机构地区：[1]上海市计划生育科学研究所

出　　处：《江西医学院学报》1995年第4期61-64,共4页Acta Academiae Medicinae Jiangxi

摘　　要：通过“结合化学分离与原子吸收分光光度法”对Ｃａ￣（２＋）含量测定和离体输卵管肌条收缩记录方法，研究米非司酮（Ｒｕ４８６）对增加假孕（４ｄ）兔输卵管平滑肌收缩频率，而不改变其收缩张力和振幅时与Ｃａ￣（２＋）之间的关系。结果提示：（１）Ｒｕ４８６对输卵管分泌液和组织内Ｃａ￣（２＋）的含量分布无明显影响；（２）Ｒｕ４８６具有降低细胞外液高Ｃａ￣（２＋）浓度促Ｃａ￣（２＋）内流，而使收缩增强的效应，且能协同Ｃａ￣（２＋）通道阻断剂（Ｖｅｒａｐａｉｎｉｌ）抑制细胞外Ｃａ￣（２＋）内流，而致收缩减弱的效应。The relation between Ca￣(2+) and the effect of Ru486 on oviductal contractihty and Ca￣(2+)content in pseudopregnant rabbits were observed by recording isolated muscular contractilitycombined with chemical separation and atomic absorption spectrophotometry technique. Theresults;showed that(1)Ru486 had no evident influence on the Ca￣(2+) content in oviductal fluidor tissue.(2) Ru486 inhibited markedly the strong isthmic contraction induced by extracellu-lar Ca￣(2+) and also had a significantly synergistic effect with Verapamil.

关 键 词：米非司酮 药效学 输卵管 RU486 CA^2+ 输卵管平滑肌收缩频率 

分 类 号：R979.22[医药卫生—药品]