原发性肾脏疾患红细胞及细胞免疫功能探讨  

An Approach into Red-cell,T-cell Immune Function in Essential Renal Diseases

作　　者：吴锦云[1] 胡欣[1] 吴外佬 何士勤[1] 张天堑 付颖媛 曾丹 

机构地区：[1]江西医学院第二附属医院肾内科,江西医学院微生物教研室,江西省劳动卫生研究所微机室

出　　处：《江西医学院学报》1994年第4期37-40,共4页Acta Academiae Medicinae Jiangxi

摘　　要：分析４０例不同原发性肾脏疾病患者外周血红细胞Ｃ＿３ｂ受体（ＲＢＣ－Ｃ＿３ｂ）、红细胞免疫复合物（ＲＢＣ－ＩＣ）、Ｔ细胞亚群（ＣＤ＿３、ＣＤ＿４、ＣＤ＿８）及Ｔ淋巴细胞转化试验（ＬＴＴ）结果。与正常人比较，ＲＢＣ－Ｃ＿３ｂ、ＣＤ＿３、ＣＤ＿４、ＣＤ＿８均下降，而ＲＢＣ－ＩＣ则升高，尿毒症患者血中ＬＴＴ值下降明显，统计处理上述结果均有非常显著差异（Ｐ＜０．０１）。各项指标作多因素相关分析发现，诸因素间存在某些相关性。提示原发性肾脏疾病患者体内存在着多种免疫功能失调，且彼此影响是导致肾脏病发生的重要原因。The C3b receptor of red blood cell(RBC-C3b),immune complex of red cell(RBC-IC),subgroups of T-cell(CD3,CD4,CD8 )and lymphocyte transformation test,in peripheralblood of patients with essential diseases of the kidney(40 cases)were reported and comparedwith those of normal suhjects. The results showed that the contents of RBC-C3b,T-cell sub-groups, were lower (P<0.01),and RBC-IC was higher (P<0. 01 )than those of normalsubtects. And the blood LTT in ureonic patients reduced evidently. Analysis of muItiple fac-tors revealed that thev were correlated to each other.It is suggested that imbalance of im-mune functions are present in patients with essential renal diseases and that their interactionis the important cause of kidney diseases.

关 键 词：肾疾病 红细胞免疫学 免疫细胞 多因素分析 

分 类 号：R692[医药卫生—泌尿科学]