β-EP和性激素在子宫内膜异位症不孕中的变化  

On the Variation of β-EP and Sex Hormones in Endometriosis-associated-infertility

作　　者：王秀丽[1] 徐琳[1] 李庆云[2] 申亚虹[1] 

机构地区：[1]昆明医学院第一附属医院妇产科,昆明650032 [2]昆明医学院第一附属医核医学科,昆明650032

出　　处：《昆明医学院学报》2001年第3期44-46,52,共4页Journal of Kunming Medical College

摘　　要：为了探讨 β -EP在内异症不孕发生中的可能作用 ,以期为临床治疗内异症不孕开辟一条新的途径 .方法 :分别制备内异症不孕、内异症、输卵管炎性阻塞性不孕兔模型 ,以内异症不孕兔为研究对象 ,内异症、输卵管炎性阻塞性不孕和正常兔为对照组 ,分别测定各组血浆 β -EP、血清FSH ,LH ,E2 ,P ,T ,PRL水平 .并分析 β -EP与性激素水平变化的相关性 .结果 :与输卵管炎性阻塞性不孕和正常兔相比 ,内异症不孕和内异症兔血 β -EP ,PRL水平增高 (P <0 0 5 ) ,LH ,E2 ,P水平降低 (P <0 0 5 ) ,内异症不孕组变化较内异症组有明显差异 (P <0 0 5 ) .提示 :内异症可能引起 β -EP分泌增高 ,高水平的 β -EP与性激素分泌紊乱密切相关 ,β -EP可能是导致内异症患者不孕率高的原因之一 .In order to find out the possible function of Beta-endorphin (β-EP) in the aetiology of endometriosis-associated-infertility (EAI) and to develop a new way to treat the EAI, EAI hares were the subjects to be tested the concentrations ofβ-EP, follicle stimulating hormone (FSH), luteinizing hormone (LH), tubal factorinfertility and normal rabbits before making animal models successfully. Analyzed were the correlation betweenβ-EP, FSH, LH, E 2, P, T, PL. In conclution, the consentrations ofβ-EP and PRL in the blood of EAI and EMT hares were higher (P<0 05) than the contrast. However, the concentrations of serum FSH, LH, E 2, P were lessened. These changes were greater (P<0 05) in EAI hares. There was a significant correlation between the concentrations ofβ-EP, FSH, LH, E 2, PRL. The secretion ofβ-EP was increased by EMT. The raisedβ-EP, one of the possible reasons which result in the EAI, correlates with reproductive endocrine disturbance.

关 键 词：子宫内膜异位症 不孕 兔 Β-内啡肽 性激素 

分 类 号：R711.71[医药卫生—妇产科学] R711.6[医药卫生—临床医学]