肾移植病人血浆粘附分子GMP－140测定的意义  

Clinical Significance of Measuring Plasma Adhesion Molecule:GMP-140 in Renal Allograft Patients

作　　者：邱平[1] 张仕光[1] 

机构地区：[1]广东肇庆市第一人民医院肾内科,中山医科大学第一附属医院肾病研究所

出　　处：《江西医学院学报》1996年第2期37-40,共4页Acta Academiae Medicinae Jiangxi

基　　金：中山医科大学读研究生的课题

摘　　要：采用ＥＬＩＳＡ方法检测６０例肾移植患者血浆ＧＭＰ－１４０水平，探讨肾移植病人血浆ＧＭＰ－１４０水平变化和意义。结果显示：环孢霉素肾中毒组血浆ＧＭＯ－１４０水平为２９２±９９ｎｇ／ｍｌ，急性排斥组血浆ＧＭＰ－１４０水平为５１５±１８７ｎｇ／ｍｌ，移植肾功能稳定组血浆ＧＭＰ－１４０水平为１１４±３０ｎｇ／ｍｌ，三组比较有显著性差异（Ｐ＜０．０１）。在研究肾功能稳定并发感染者发现，此组病人血浆ＧＭＰ－１４０水平也显著升高为５７５±１７２ｎｇ／ｍｌ，与急性排斥组比较无显著性差异（Ｐ＞０．０５）。提示监测肾移植病人血浆ＧＭＰ－１４０水平有助于诊断急性排斥和鉴别环孢毒素肾中毒。The level of plasma GMP-140 in 60 renal allograft patients was determined to study itschanges and clinical significance,The results showed:The plasma GMP-140 level in patientswith CsA nephrotoxification was 292±99 ng/ml,that in patients with acute rejection was515±187 ng/ml and that in patients with stable renal function was 114±30 ng/ml.There isstatistically significant difference(P< 0.01)among the three groups. In patients of stablerenal function but complicated with infection the plasma GMP-140 level was raised markedly(535 ±172ng/ml),without significant difference(P>0.05)as compared with that in thegroup of acute of rejection. It is suggested that monitoring of plasma GMP-140 level in renalallograft patients are helpful for diagnosing acute rejection and distinguishing CsAnephrotoxification.

关 键 词：异体移植 GMP-140 肾移植 对比研究 血浆粘附分子 免疫反应 异体排斥 

分 类 号：R699.2[医药卫生—泌尿科学]