白花前胡丙素与类似物的化学沟通  

The Chemical Correlation between (+)-Praeruptorin A and its Similar Compounds

作　　者：孔令义[1] 吴献礼[1] 闵知大[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210038

出　　处：《中国药科大学学报》2001年第5期339-341,共3页Journal of China Pharmaceutical University

基　　金：国家自然科学基金 ( No. 2 9872 0 5 8);高等学校优秀青年教师教学科研奖励计划资助项目

摘　　要：目的 :将白花前胡丙素与其类似物进行化学沟通 ,为进一步进行结构修饰奠定基础。方法 :控制碱水解条件 ,得到白花前胡丙素的三个水解产物 ,采用在二氯甲烷溶剂中与相应的酸直接酰化的方法得到各种类似物。结果 :合成了三种白花前胡的类似物 ,即 3′( S) -当归酰氧基 -4′( R) -异戊酰氧基 -3′,4′-二氢邪蒿内酯、3′( S) ,4′( S) -二乙酰氧基 -3′,4′-二氢邪蒿内酯和 3′( S) ,4′( R) -二乙酰氧基 -3′,4′-二氢邪蒿内酯。结论 :合成的三个白花前胡丙素的类似物中 ,两个为新化合物 。AIM The chemical correlation between (+) praeruptorin A and its similar compounds was conducted, which lay a good foundation for the further structural modification of (+) praeruotorin A METHODS Controlling the conditions of basic hydrolysis, three hydrolysis products were obtained which further acylated with acids in dichloromethane to give the similar compounds RESULTS Three similar compounds, 3′( S ) angeloyloxy 4′( R ) isovaleryloxy 3′,4′ dihydroseselin, 3′( S),4′(S ) diacetoxy dihydroseselin, 3′( S),4′(R ) diacetoxy 3′,4′ dihydroseselin, were semisynthesized CONCLUSION Among the three similar compounds, two were new compounds, and another one was a known natural products

关 键 词：白花前胡丙素 化学沟通 类似物 结构修饰 

分 类 号：R284[医药卫生—中药学]