结核性脑膜炎脑脊液中磷脂酶A2活性测定及其临床意义  

Clinical significance of phospho lipase A2 activity in cerebrospinal flui d of patients with tuberculous meningitis.

作　　者：李廷富[1] 涂植光[2] 张薇[1] 黄永忠[1] 

机构地区：[1]泸州医学院附属医院,四川泸州646000 [2]重庆医科大学,重庆40016

出　　处：《四川医学》2001年第8期744-745,共2页Sichuan Medical Journal

摘　　要：目的　探讨结核性脑膜炎脑脊液中磷脂酶 A2 (PL A2 )活性变化及其临床意义。方法　采用 [3H]-油酸标记大肠杆菌膜为底物测定结核性脑膜炎患者脑脊液和对照组脑脊液中 PL A2活力。结果　结脑患者组脑脊液 PL A2活力显著高于对照组 ,经抗结核药物加地塞米松、或强的松等激素治疗后 ,PL A2活力显著下降 ;对照组脑脊液 PL A2活力极低 ,且少儿组与成人组 PL A2活力无显著性差别 ;相关性分析显示 PL A2活力与相应的 WBC、Cl- 、Pro、Glu均无显著性相关关系。结论　 PLObjective To inves tigate the change of the phospholipase A 2(PLA2) activity in cerebrospinal fluid (CSF) of patients and its clinical signi ficance.Methods The PLA2 activ ities in CSF of 55 patients with tubercu lous meningitis (TM) and 32 cases of non -neurologic patients as controls were de termined by radiochemical assay using oleic acid labled Escherichia Coli a s substrate.Results The PL- activity in CSF of the TM was significa ntly higher than that of controls.Howeve r,the PL- activity in CSF of the TM gro up decreased significantly after the tre atment with antituberculous drugs and gl ucocorticoids such as dexamethasone,pred nisone,and so on.The PL- activity in CS F of controls was very low and there was no significant difference between the c hildren and the adult control groups.The results of correlation analysis suggest ed that there was no correlation between the PL- activity and the levels of WBC ,Cl -,Pro and Glu.Conclusion PL- as a potent proinflammatory factor may play an important role in the cours e of TM.

关 键 词：磷脂酶A2 脑脊液 结核性脑膜炎 临床意义 

分 类 号：R529.3[医药卫生—内科学]