对氟苄胺合成工艺的改进  

Improvement of synthetic process of p-fluorobenzylamine

作　　者：李敬芬[1] 李彬[1] 周淑静[1] 王书红[1] 

机构地区：[1]佳木斯大学化学与药学院,佳木斯154007

出　　处：《中国现代应用药学》2001年第5期367-369,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：佳木斯大学校管课题基金的资助

摘　　要：目的 :获得成本低、工艺简单的合成方法。方法 :以对硝基苯甲酸为原料经氟化、酰化和还原 3步合成药物中间体对氟苄胺。结果 :总收率达 3 0 .4 3 %。结论 :新的合成方法具有原料易得、成本低廉。OBJECTIVE:To simplify the method of synthesizing p fluorobenzylamine and low the cost of raw material. METHOD:p Fluorobenzylamine, which is the intermediate compound of some medicine, was synthesized by 3 steps with p Nitrobenzoic acid as starting material. The 3 steps were fluorization, acylation and reduction. RESULTS:The overall yield was 30.43%. CONCLUSION:The process was simple and safe. The raw material was abundant and its cost was low.

关 键 词：对氟苄胺 对硝基苯甲酸 合成 工艺改进 药物中间体 

分 类 号：TQ460.4[化学工程—制药化工]