皮炎消净饮I号冲剂治疗异位性皮炎的实验研究  

Experimental study on the treatment of atopic dermatitis by Pi Yan Xiao Jing Ying I

作　　者：朱金土[1] 余土根[1] 杨锋[2] 任永葆[1] 

机构地区：[1]浙江省中医院,杭州310006 [2]浙江省中医药研究院,杭州310007

出　　处：《中国现代应用药学》2001年第5期411-412,共2页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省中医管理局科研工项目 (合同号 95 0 31)

摘　　要：目的 :研究皮炎消净饮 I号冲剂 ( PYXJYl)治疗异位性皮炎 ( AD)的作用机理。方法 :1动物实验 :二硝基氯苯 ( DNCB)所致豚鼠耳肿试验 ,致敏处真皮内单核细胞和淋巴细胞聚集试验 ;醋酸所致小鼠腹腔毛细血管通透性增加试验。 2实验室检测 :单克隆抗体免疫荧光标记法检测 AD患者治疗前后的 CD4 / CD8( TH/ TS)水平。结果 :PYXJY 1可明显抑制二硝基氯苯所致豚鼠耳肿胀及其真皮内单核细胞和淋巴细胞聚集 ,抑制醋酸所致小鼠腹腔毛细血管通透性的增加 ,作用与氢化可的松相似。使AD患者升高的 CD4 / CD8降低至正常。结论 :PYXJY1具有良好的抗炎和抗迟发变态反应作用 ,并可调节 AD患者 CD4 / CD8水平 ,对OBJECTIVE:To study the mechanism of functions on the treatment of atopic dermatitis(AD) by Pi Yan Xiao Jing Yin 1 ( PYXJY1 )METHOD:①Animal model: The rat's ears swollen test, counts of monocyte and lymphocyte in allergic dermatitis which caused by DNCB. The test of the higher capillary permeablity which caused by acetic acid. ②The monoclonal antibody immunofluorescence technic applied to detect levels of the CD 4/CD 8(T H/T S) in patients with AD. RESULTS:PYXJY1 obviously limited the rat's ears swallen, counts of monocyte and lymphocyte in allergic dermatitis which caused by DNCB,and limited the higher capillary permeablity which caused by acetic acid. Its function is similar as cortisone,having reduced levels of the CD 4/CD 8 to normal in patients with AD.CONCLUSION:PYXJY1 is effective for the anti inflammation and delayed allergic reaction. It adjusted levels of CD 4/CD 8 in patients with AD.

关 键 词：皮炎消净饮I号 异位性皮炎 炎症 迟发性变态反应 中医药疗法 治疗 实验研究 

分 类 号：R285.5[医药卫生—中药学] R275.982[医药卫生—中医学]