氟伐他汀对肾衰大鼠肾脏纤维化病变进展影响及机制探讨  

The Effects and Mechanism of Fluvastatin on Renal Fibratic Rats

作　　者：王翠玲[1] 李建先[1] 刘源[1] 郝翼中[1] 

机构地区：[1]山西医科大学第一医院,太原030001

出　　处：《中国中西医结合肾病杂志》2001年第6期321-324,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：山西省卫生厅 85攻关资助项目(№ .982 1)

摘　　要：目的 :探讨丙戊二酸辅酶A(HMG -CoA)还原酶抑制剂 -氟伐他汀 (Fluvastatin)在慢性进展性肾小球硬化和肾小管间质纤维化过程中对肾血管损伤、肾脏细胞外基质产生和降解过程中的影响。方法 :采用 5 / 6肾切除SD大鼠制备肾小球硬化及慢性肾衰实验动物模型 ,予氟伐他汀治疗后分别于治疗开始、治疗后第 4周、第 8周时间点观察大鼠血脂、尿蛋白、肾功能及血压变化 ,并评价该药对肾小球及小管间质组织病理学变化的干预作用。结果 :氟伐他汀可降血压、减少蛋白尿、降低血脂、改善肾功能、防止和逆转肾血管硬化、狭窄。并通过影响PAI- 1uPA等因子的表达而阻抑肾脏细胞外基质的产生 ,促进其降解。结论Objective: To investigate the effects of Fluvastatin on renal vascular lesions and production and degradation of extracellular matix(ECM) during the evolution of glomerulosclerosis and tubulointerstitial fibrosis.Methods:5/6 nephrectomized SD rats were used as experimental model.At different time points after being treated with Fluvastatin,serum and urinary biochemical parameters, renal function and blood pressure were measured respectively. The effects of this agent on renal lesions were estimated by PAS and immunohistochemical staining.Results:Blood pressure,proteinuria, hyperlipidemia and renal function were improved significantly in treated group. The PAS staining showed that renal parenchymal and vascular damages improved markedly. The results of immunohistochenical staining showed that protein expression of PAI-1 in renal tissues decreased and uPA expression increased in the treated group.Conclusion: Fluvastatin has an important effect to improve the glomerulosclerosis and tubulointerstitial fibrosis.

关 键 词：肾切除 肾小球硬化 肾小管间质纤维化 氟伐他汀 肾功能衰竭 

分 类 号：R965[医药卫生—药理学]