取代吡唑并[4,5-e][1,3]噻嗪衍生物的合成及生物活性  

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SUBSTITUTED PYRAZOLO [4,5 e][1,3]THIAZINE DERIVATIVES

作　　者：金桂玉[1] 曹春阳[1] 李林涛 任军[1] 赵国锋[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室南开大学元素有机化学研究所,天津300071

出　　处：《农药学学报》1999年第1期15-19,共5页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金! (批准号 2 9832 0 50 )资助课题

摘　　要：取代吡唑酰基异硫氰酸酯与杂环胺、磺酰胺反应 ,得到了加成产物取代吡唑酰基硫脲或关环产物吡唑并 [4 ,5- e][1,3]噻嗪。取代吡唑酰基硫脲化合物在三乙胺作用下也关环成吡唑并 [4 ,5- e][1,3]噻嗪。化合物结构均经 1HNMR、IR及元素分析确证 ,并对此加成、环化反应结果和机理进行了讨论。初步生物活性测试表明 ,这些化合物具有一定的杀菌。The additive compounds substituted pyrazolyl thiourea (II) or cyclic pyrazolo [4,5 e][1,3]thiazines (III) were obtained by reaction of heterocyclic (sulfonyl) amines with substituted pyrazolyl isothiocyanates. Compounds (II) were cyclized in the presence of triethylamine to give compounds (III) respectively. The structures of compounds (II) and (III) were conformed by 1H NMR, IR, MS and elemental analysis and the reaction results were discussed. The preliminary bioassay presented that some of compounds showed fungicidal, herbicidal and plant growth regulatory activities.

关 键 词：吡唑酰基硫脲 噻嗪 加成 环化 生物活性 取代吡唑并[4 5-e][1 3]噻嗪衍生物 农药 

分 类 号：TQ450.21[化学工程—农药化工]