涂敷型直链淀粉手性固定相的制备及对外消旋体农药喹禾灵的分离研究  

Chiral Separation of Quizalofop on Amylose-Chiral Stationary Phase by HPLC

作　　者：周志强[1] 江树人[1] 王敏[1] 钱传范[1] 杨舰[2] 

机构地区：[1]中国农业大学应用化学系,北京100094 [2]中国农业科学院植物保护研究所,北京100094

出　　处：《农药学学报》2000年第1期91-93,共3页Chinese Journal of Pesticide Science

摘　　要：Amylose tris(3,5 dimethphenylcarbamate) was synthesized and used as the chiral stationary phase upon adsorption over silica gel. This stationary phase offered a practically useful chiral column with a high enantiomer separability. Amylose was allowed to react with an excess of 3,5 dimethphenylcarbamate in pyridine for 48h. The obtained carbamate was dissolved and adsorbed on silica gel which has been treated with 3 aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0.45/2.55. The quizalofop was resoluted on amylose tris(3,5 dimethphenylcarbamate) chiral stationary phase. Separation was carried out with a hexane/2 propanol mixture at a flow rate of 0.5 mL·min -1 at room temperature. The effects of 2 propanol concentration on the retention and resolution had been investigated.Amylose tris(3,5 dimethphenylcarbamate) was synthesized and used as the chiral stationary phase upon adsorption over silica gel. This stationary phase offered a practically useful chiral column with a high enantiomer separability. Amylose was allowed to react with an excess of 3,5 dimethphenylcarbamate in pyridine for 48h. The obtained carbamate was dissolved and adsorbed on silica gel which has been treated with 3 aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0.45/2.55. The quizalofop was resoluted on amylose tris(3,5 dimethphenylcarbamate) chiral stationary phase. Separation was carried out with a hexane/2 propanol mixture at a flow rate of 0.5 mL·min -1 at room temperature. The effects of 2 propanol concentration on the retention and resolution had been investigated.

关 键 词：高效液相色谱 直链淀粉-三(3 5-二甲基苯基氨基甲酸酯) 喹禾灵 手性拆分 农药 分离 对外消旋体 涂敷型 除草剂 

分 类 号：TQ450.7[化学工程—农药化工] TQ457